rCBF For Middle-Aged Males and Females During Right-Left Discrimination

Hannay, H. Julia; Leli, Dano A.; Falgout, Janet C.; Katholi, Charles R.; Halsey, James H.

doi:10.1016/s0010-9452(83)80028-8

Cited by 29 publications

(16 citation statements)

References 27 publications

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“…Only one rather old imaging study has looked at the underlying neuro-cognitive mechanism for sex differences in left-right confusion. However, no differences between men and women were found (Hannay et al, 1983). In this study, the spatial resolution of the applied imaging method was too low to investigate detailed anatomical involvement in men and women, which might partly explain the lack of a sex difference finding in brain activation.…”

Section: Introductionmentioning

confidence: 69%

“…The few neuroimaging studies on LRD conducted on healthy participants mostly confirm the findings from previous lesion studies. Two rather old imaging studies found bilateral occipital (Hannay et al, 1983;Leli et al, 1982), as well as bilateral parietal (Leli et al, 1982), and the left parietal (Hannay et al, 1983) increase in blood flow during LRD. The particular involvement of the left hemisphere is further supported by a more recent transcranial magnetic stimulation (TMS) study , which showed that repetitive TMS (1 Hz) over the left angular gyrus disrupts LRD, as compared to TMS over the right angular gyrus.…”

Section: Introductionmentioning

confidence: 94%

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The neural correlates of sex differences in left–right confusion

et al. 2015

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Difficulties in left-right discrimination (LRD) are commonly experienced in everyday life situations. Here we investigate the neurocognitive mechanisms of LRD and the specific role of left angular gyrus. Given that previous behavioral research reported women to be more susceptible to left-right confusion, the current study focuses particularly on the neural basis of sex differences in LRD while controlling for potential menstrual cycle effects (repeated measures design). 16 women and 15 men were presented pictures of pointing hands in various orientations (rotated versus non-rotated) and were asked to identify them as left or right hands. Results revealed that LRD was particularly associated with activation in inferior parietal regions, extending into the right angular gyrus. Irrespective of menstrual cycle phase, women, relative to men, recruited more prefrontal areas, suggesting higher top-down control in LRD. For the subset of rotated stimuli as compared to the non-rotated, we found leftward asymmetry for both men and women, although women scored significantly lower. We conclude that there are sex differences in the neurocognitive mechanisms underlying LRD. Although the angular gyrus is involved in LRD, several other parietal areas are at least as critical. Moreover, the hypothesis that more left-right confusion is due to more bilateral activation (in women) can be rejected.

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Section: Introductionmentioning

confidence: 69%

Section: Introductionmentioning

confidence: 94%

The neural correlates of sex differences in left–right confusion

et al. 2015

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“…While some studies reported no gender differences in CBF (Melamed et al, 1980;Hannay et al, 1983), others found that women had higher rates of CBF than men and that was related to age, since by the sixth decade (Gur et al, 1987) men and women had similar flow rates. PET (Rodriguez et al, 1988;Gur and Gur, 1990;Jaeger et al, 1998;Ragland et al, 2000) and fMRI (Kastrup et al, 1999) studies found differences in activation during resting state (Rodriguez et al, 1988), cognitive tasks (Gur and Gur, 1990;Jaeger et al, 1998;Ragland et al, 2000), or visual stimulation (Kastrup et al, 1999).…”

Section: Gender Differences In Activationmentioning

confidence: 95%

Distinct pathways involved in sound recognition and localization: A human fMRI study

Maeder¹,

Meuli²,

Adriani³

et al. 2000

NeuroImage

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Evidence from psychophysical studies in normal and brain-damaged subjects suggests that auditory information relevant to recognition and localization are processed by distinct neuronal populations. We report here on anatomical segregation of these populations. Brain activation associated with performance in sound identification and localization was investigated in 18 normal subjects using fMRI. Three conditions were used: (i) comparison of spatial stimuli simulated with interaural time differences; (ii) identification of environmental sounds; and (iii) rest. Conditions (i) and (ii) required acknowledgment of predefined targets by pressing a button. After coregistering, images were normalized and smoothed. Activation patterns were analyzed using SPM99 for individual subjects and for the whole group. Sound recognition and localization activated, as compared to rest, inferior colliculus, medial geniculate body, Heschl gyrus, and parts of the temporal, parietal, and frontal convexity bilaterally. The activation pattern on the fronto-temporo-parietal convexity differed in the two conditions. Middle temporal gyrus and precuneus bilaterally and the posterior part of left inferior frontal gyrus were more activated by recognition than by localization. Lower part of inferior parietal lobule and posterior parts of middle and inferior frontal gyri were more activated, bilaterally, by localization than by recognition. Regions selectively activated by sound recognition, but not those selectively activated by localization, were significantly larger in women. Passive listening paradigm revealed segregated pathways on superior temporal gyrus and inferior parietal lobule. Thus, anatomically distinct networks are involved in sound recognition and sound localization.

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“…The absence of a similar asymmetrical pattern in women is, how ever, pUzzling. It may indicate true sex differences in the organization of the cerebral cortex (Hannay et al, 1983;Warkentin et al, 1986) but may also reflect sex-related differences in the functional state of the brain during the examination period, e.g., more verbal activity in resting women.…”

Section: Asymmetriesmentioning

confidence: 99%

Sex Differences in Regional Cerebral Blood Flow

Rodriguez¹,

Warkentin

Risberg

et al. 1988

J Cereb Blood Flow Metab

248

126

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Summary: Regional cerebral blood flow was measured by the 133-xenon inhalation method during resting in 38 healthy men and 38 healthy women matched pairwise for age in the range 18-72 years. The results showed 11 % higher global flow level in the women in all ages. A sim ilar and significant regression of flow by age was seen for both sexes. The regional flow distribution also showed some sex-related differences. Frontal regions showed an asymmetry in the men with higher values on the right

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rCBF For Middle-Aged Males and Females During Right-Left Discrimination

Cited by 29 publications

References 27 publications

The neural correlates of sex differences in left–right confusion

The neural correlates of sex differences in left–right confusion

Distinct pathways involved in sound recognition and localization: A human fMRI study

Sex Differences in Regional Cerebral Blood Flow

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