Re-analysis of hepatitis B virus integration sites reveals potential new loci associated with oncogenesis in hepatocellular carcinoma

Kojima, Ryuta; Nakamoto, Shingo; Kogure, Tadayoshi; Ma, Yaojia; Ogawa, Keita; Iwanaga, T.; Qiang, Na; Ao, Junjie; Nakagawa, Ryo; Muroyama, Ryosuke; Nakamura, Masato; Chiba, Tetsuhiro; Kato, Jun; Kato, Naoya

doi:10.5501/wjv.v12.i3.209

Cited by 3 publications

(1 citation statement)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Kojima et al . (Kato lab, Chiba University) developed an algorithm (GRIDSS VIRUSBreakend) to map HBV DNA integrations from next-generation sequencing data [25]. Other groups targeted biological sources; Liu et al .…”

Section: Hbv Integrants and Viral Pathogenesismentioning

confidence: 99%

Highlights from the 2023 International Meeting on the Molecular Biology of Hepatitis B virus

Allweiss,

Cohen,

Dias

et al. 2024

Journal of General Virology

View full text Add to dashboard Cite

Since its discovery in 1965, our understanding of the hepatitis B virus (HBV) replication cycle and host immune responses has increased markedly. In contrast, our knowledge of the molecular biology of hepatitis delta virus (HDV), which is associated with more severe liver disease, is less well understood. Despite the progress made, critical gaps remain in our knowledge of HBV and HDV replication and the mechanisms underlying viral persistence and evasion of host immunity. The International HBV Meeting is the leading annual scientific meeting for presenting the latest advances in HBV and HDV molecular virology, immunology, and epidemiology. In 2023, the annual scientific meeting was held in Kobe, Japan and this review summarises some of the advances presented at the Meeting and lists gaps in our knowledge that may facilitate the development of new therapies.

show abstract

Section: Hbv Integrants and Viral Pathogenesismentioning

confidence: 99%

Highlights from the 2023 International Meeting on the Molecular Biology of Hepatitis B virus

Allweiss,

Cohen,

Dias

et al. 2024

Journal of General Virology

View full text Add to dashboard Cite

show abstract

The impact of integrated hepatitis B virus DNA on oncogenesis and antiviral therapy

Zhang,

Chen,

Liu

et al. 2024

Biomark Res

View full text Add to dashboard Cite

The global burden of hepatitis B virus (HBV) infection remains high, with chronic hepatitis B (CHB) patients facing a significantly increased risk of developing cirrhosis and hepatocellular carcinoma (HCC). The ultimate objective of antiviral therapy is to achieve a sterilizing cure for HBV. This necessitates the elimination of intrahepatic covalently closed circular DNA (cccDNA) and the complete eradication of integrated HBV DNA. This review aims to summarize the oncogenetic role of HBV integration and the significance of clearing HBV integration in sterilizing cure. It specifically focuses on the molecular mechanisms through which HBV integration leads to HCC, including modulation of the expression of proto-oncogenes and tumor suppressor genes, induction of chromosomal instability, and expression of truncated mutant HBV proteins. The review also highlights the impact of antiviral therapy in reducing HBV integration and preventing HBV-related HCC. Additionally, the review offers insights into future objectives for the treatment of CHB. Current strategies for HBV DNA integration inhibition and elimination include mainly antiviral therapies, RNA interference and gene editing technologies. Overall, HBV integration deserves further investigation and can potentially serve as a biomarker for CHB and HBV-related HCC.

show abstract

Viral Oncogenesis: Synergistic Role of Genome Integration and Persistence

La Frazia,

Pauciullo,

Zulian

et al. 2024

Viruses

View full text Add to dashboard Cite

Persistence is a strategy used by many viruses to evade eradication by the immune system, ensuring their permanence and transmission within the host and optimizing viral fitness. During persistence, viruses can trigger various phenomena, including target organ damage, mainly due to an inflammatory state induced by infection, as well as cell proliferation and/or immortalization. In addition to immune evasion and chronic inflammation, factors contributing to viral persistence include low-level viral replication, the accumulation of viral mutants, and, most importantly, maintenance of the viral genome and reliance on viral oncoprotein production. This review focuses on the process of genome integration, which may occur at different stages of infection (e.g., HBV), during the chronic phase of infection (e.g., HPV, EBV), or as an essential part of the viral life cycle, as seen in retroviruses (HIV, HTLV-1). It also explores the close relationship between integration, persistence, and oncogenesis. Several models have been proposed to describe the genome integration process, including non-homologous recombination, looping, and microhomology models. Integration can occur either randomly or at specific genomic sites, often leading to genome destabilization. In some cases, integration results in the loss of genomic regions or impairs the regulation of oncogene and/or oncosuppressor expression, contributing to tumor development.

show abstract

Re-analysis of hepatitis B virus integration sites reveals potential new loci associated with oncogenesis in hepatocellular carcinoma

Cited by 3 publications

References 28 publications

Highlights from the 2023 International Meeting on the Molecular Biology of Hepatitis B virus

Highlights from the 2023 International Meeting on the Molecular Biology of Hepatitis B virus

The impact of integrated hepatitis B virus DNA on oncogenesis and antiviral therapy

Viral Oncogenesis: Synergistic Role of Genome Integration and Persistence

Contact Info

Product

Resources

About