Re: "Decreased Risk of CEliac Disease in Patients With Helicobacter Pylori Colonization"

Mooney, Peter D.; Evans, K E; Barrett, S M; Arnaout, A. H.; Sanders, David S.

doi:10.1093/aje/kwu054

Cited by 3 publications

(4 citation statements)

References 5 publications

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“…HP is associated with decreased risks of allergic and atopic disease and other inflammatory conditions . This may be due to theory called “hygiene hypothesis” in which reduced exposure to infective antigens in childhood as Western environments become cleaner leads to an increased risk of autoimmunity . There may also be altered T‐cell response in patients with HP .…”

Section: Discussionmentioning

confidence: 99%

“…[28][29][30] This may be due to theory called "hygiene hypothesis" in which reduced exposure to infective antigens in childhood as Western environments become cleaner leads to an increased risk of Celiac disease and Helicobacter pylori autoimmunity. 31,32 There may also be altered T-cell response in patients with HP. 33,34 T-regulatory lymphocytes may be involved in CD pathogenesis, because the downregulation of cellular responses mediated by these regulatory cells is diminished in CD patients.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Celiac disease and Helicobacter pylori infection in children: Is there any Association?

Narang

Puri

Sachdeva

et al. 2017

J of Gastro and Hepatol

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Celiac disease and Helicobacter pylori infection in children: Is there any Association?

Narang

Puri

Sachdeva

et al. 2017

J of Gastro and Hepatol

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“…This suggests that there is more to the development of coeliac disease than genetic predisposition. Multiple trigger factors have been proposed such as preceding gastrointestinal infection [25,26] or exposure to gluten early in life [27]. The protective effects of a normal vaginal birth [28], Helicobacter pylori infection [29] and breast feeding [30] have also been proposed.…”

Section: Pathogenesis Of Coeliac Diseasementioning

confidence: 99%

Emerging drugs for coeliac disease

Mooney

Hadjivassiliou

Sanders

2014

Expert Opinion on Emerging Drugs

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There is clearly an unmet need for alternatives to a GFD for the treatment of coeliac disease. Oral glutenase supplements to improve the degradation of gluten into non-toxic peptides appear to be the most likely to provide a breakthrough in the treatment of coeliac disease; however, other modalities such as a therapeutic vaccine or zonulin inhibitors to reduce intestinal permeability have shown promising results.

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“…Otherwise, some researchers claimed that H. pylori may be involved in the development of CeD. Mooney et al mentioned that maybe H. pylori acts as an environmental trigger for CeD, as observed in Campylobacter infection, in a study of the US military [21,30]. However, the mechanism of this act is not properly defined.…”

Section: Introductionmentioning

confidence: 99%

A systematic review and meta-analysis for association of Helicobacter pylori colonization and celiac disease

et al. 2021

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Background and objectives Based on some previous observational studies, there is a theory that suggests a potential relationship between Helicobacter pylori (H. pylori) colonization and celiac disease (CeD); however, the type of this relationship is still controversial. Therefore, we aimed to conduct a systematic review and meta-analysis to explore all related primary studies to find any possible association between CeD and human H. pylori colonization. Data sources Studies were systematically searched and collected from four databases and different types of gray literature to cover all available evidence. After screening, the quality and risk of bias assessment of the selected articles were evaluated. Synthesis methods Meta-analysis calculated pooled odds ratio (OR) on the extracted data. Furthermore, heterogeneity, sensitivity, subgroups, and publication bias analyses were assessed. Results Twenty-six studies were included in this systematic review, with a total of 6001 cases and 135512 control people. The results of meta-analysis on 26 studies showed a significant and negative association between H. pylori colonization and CeD (pooled OR = 0.56; 95% CI = 0.45–0.70; P < 0.001), with no publication bias (P = 0.825). The L’Abbé plots also showed a trend of having more H. pylori colonization in the control group. Among subgroups, ORs were notably different only when the data were stratified by continents or risk of bias; however, subgroup analysis could not determine the source of heterogeneity. Conclusions According to the meta-analysis, this negative association might imply a mild protective role of H. pylori against celiac disease. Although this negative association is not strong, it is statistically significant and should be further considered. Further investigations in both molecular and clinic fields with proper methodology and more detailed information are needed to discover more evidence and underlying mechanisms to clear the interactive aspects of H. pylori colonization in CeD patients. Systematic review registration number (PROSPERO) CRD42020167730 https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=167730.

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Re: "Decreased Risk of CEliac Disease in Patients With Helicobacter Pylori Colonization"

Cited by 3 publications

References 5 publications

Celiac disease and Helicobacter pylori infection in children: Is there any Association?

Celiac disease and Helicobacter pylori infection in children: Is there any Association?

Emerging drugs for coeliac disease

A systematic review and meta-analysis for association of Helicobacter pylori colonization and celiac disease

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