Re: Effectiveness of Vitamin B12 in Treating Recurrent Aphthous Stomatitis: A Randomized, Double-Blind, Placebo-Controlled Trial

Burgess, J Hay

doi:10.3122/jabfm.2009.05.090083

Cited by 2 publications

(1 citation statement)

References 2 publications

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“…From 76 unique studies, we excluded 33 (Figure 1): 11 studies that did not test RAS treatments (Arvola et al , 2006; Sunitha and Shanmugam, 2006; Akman et al , 2007; Yoshihara et al , 2007; van der Hilst et al , 2008; Yao et al , 2008; Lebranchu et al , 2009; Chams‐Davatchi et al , 2010; Davatchi et al , 2010; Erkalp et al , 2010; Perico et al , 2010), 11 studies without a statistical comparison to a control arm (Kaufman et al , 2005; Sharquie and Hayani, 2005; Akhionbare and Ojehanon, 2007; Sharma et al , 2007; Karaca et al , 2008; Lee et al , 2008; Nanke et al , 2008; Mimura et al , 2009; Ciancio et al , 2010; Hello et al , 2010; Yasui et al , 2010), and eleven other studies (Moezzi et al , 2005; Brignone et al , 2007; Chuang and Langone, 2007; Passarini et al , 2007; Renko et al , 2007; Burgess, 2009; Garavello et al , 2009; Koray et al , 2009; Pignatello et al , 2009; Volkov et al , 2009Budde et al , 2011).…”

Section: Resultsmentioning

confidence: 99%

Urban legends: recurrent aphthous stomatitis

et al. 2011

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Recurrent aphthous stomatitis (RAS) is the most common idiopathic intraoral ulcerative disease in the USA. Aphthae typically occur in apparently healthy individuals, although an association with certain systemic diseases has been reported. Despite the unclear etiopathogenesis, new drug trials are continuously conducted in an attempt to reduce pain and dysfunction. We investigated four controversial topics: (1) Is complex aphthosis a mild form of Behçet’s disease (BD)? (2) Is periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome a distinct medical entity? (3) Is RAS associated with other systemic diseases (e.g., celiac disease and B12 deficiency)? (4) Are there any new RAS treatments? Results from extensive literature searches, including a systematic review of RAS trials, suggested that: (1) Complex aphthosis is not a mild form of BD in North America or Western Europe; (2) Diagnostic criteria for PFAPA have low specificity and the characteristics of the oral ulcers warrant further studies; (3) Oral ulcers may be associated with celiac disease; however, these ulcers may not be RAS; RAS is rarely associated with B12 deficiency; nevertheless, B12 treatment may be beneficial, via mechanisms that warrant further study; (4) Thirty-three controlled trials published in the past 6 years reported some effectiveness, though potential for bias was high.

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Section: Resultsmentioning

confidence: 99%

Urban legends: recurrent aphthous stomatitis

et al. 2011

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Prevalence of aphthous stomatitis or recurrent aphthous ulcers in dental students

Sharma¹,

Dua

Sharma³

et al. 2022

JOOO

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Aphthous stomatitis is a painful and recurrent inflammatory disorder affecting oral mucosa. It appears as oral manifestation of various diseases. It affects approximately 20% of the general population. Its etiopathogenesis is still unknown. Various risk factors and environmental factors are linked with its pathogenesis. Recently its association with stress has been emphasised in various studies. We tried to find out the most common site and cause of ulcerations in our subjects. A cross-sectional survey was conducted on 314 dental students by distributing a questionnaire via Google forms platform. Aphthae were most commonly seen on the lower labial mucosa and significant correlation with the mental stress was seen. The study concluded with acorrelation between stress of examinations and work deadlines to be an important factor behind the episodes of aphthous ulcer in dental students.

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Re: Effectiveness of Vitamin B12 in Treating Recurrent Aphthous Stomatitis: A Randomized, Double-Blind, Placebo-Controlled Trial

Cited by 2 publications

References 2 publications

Urban legends: recurrent aphthous stomatitis

Urban legends: recurrent aphthous stomatitis

Prevalence of aphthous stomatitis or recurrent aphthous ulcers in dental students

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