Re: Efficacy of Prilocaine-Lidocaine Cream in the Treatment of Premature Ejaculation

Şahın, Hayrettin; Bircan, Mehmet Kamuran

doi:10.1016/s0022-5347(01)65527-7

Cited by 16 publications

(7 citation statements)

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“…Additionally, residual topical anesthetics on penis may diffuse into vaginal wall. This may result in numbness in the partner (18). Continuous use of alpha blockers was easy to compliance in our series.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Alpha Blockers in Treatment of Premature Ejaculation: A Pilot Clinical Trial

Akın¹,

Gulmez²,

Ateş³

et al. 2013

Iran Red Crescent Med J

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Background:Premature ejaculation (PE) is the most common sexual disorder in men and studies reported prevalence up to 30% (1, 2). PE is not a life-threatening medical condition but it influences the quality of life (QoL).Objectives:The aim of this study was to compare the efficiency, and safety of alpha blocker drugs in the treatment of patients with premature ejaculation (PE). Additionally we investigated the quality of life (QoL) in patients with PE who were treated with alpha blocker drugs.Materials and Methods:This study was a pilot clinical trial. Prospectively documented 108 patients with PE were treated and were followed-up in urology outpatient clinic. All patients were divided into 5 groups according to used alpha blocker agents which were determined by simple randomization. Silodosin 4mg (Group 1, n = 21), tamsulosin hydrochloride 0.4mg (Group 2, n = 23), alfuzosin 10mg (Group 3, n = 22), terazosin 5mg (Group 4, n = 21), doksazosin mesylate 4mg (Group5, n = 21), were used for treatment. The demographic parameters of patients, pre and post treatment intravaginal ejaculation latency time (IELT), PE Profile (PEP), and QoL index were recorded and evaluated. Effectiveness of treatment was evaluated by measuring IELT. Additionally, side effects of drugs were recorded. P < 0.05 was considered statistically significant.Results:All alpha blocker drugs were statistically effective for preventing PE. Notably, silodosin seemed to be more effective for preventing PE than other alpha blockers (P < 0.05). However all alpha blockers provided development in QoL scores, silodosin was a little better than other drugs in statistical analyses. Furthermore statistical increase in IELT and decrease in PEP were provided more in Group 1 than other groups (P < 0.05).Conclusions:Silodosin seems to be able to even more prevent PE. Silodosin may provide development in QoL than other alpha blocker agents. Additionally, lower systemic adverse events and more effectivity are the prominent features of silodosin in PE.This study was a pilot clinical trial. Prospectively documented 108 patients with PE were treated and were followed-up in urology outpatient clinic. All patients were divided into 5 groups according to used alpha blocker agents which were determined by simple randomization. Silodosin 4mg (Group 1, n = 21), tamsulosin hydrochloride 0.4mg (Group 2, n = 23), alfuzosin 10mg (Group 3, n = 22), terazosin 5mg (Group 4, n = 21), doksazosin mesylate 4mg (Group5, n = 21), were used for treatment. The demographic parameters of patients, pre and post treatment intravaginal ejaculation latency time (IELT), PE Profile (PEP), and QoL index were recorded and evaluated. Effectiveness of treatment was evaluated by measuring IELT. Additionally, side effects of drugs were recorded. P < 0.05 was considered statistically significant.

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Section: Discussionmentioning

confidence: 99%

Comparison of Alpha Blockers in Treatment of Premature Ejaculation: A Pilot Clinical Trial

Akın¹,

Gulmez²,

Ateş³

et al. 2013

Iran Red Crescent Med J

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“…The use of topical local anesthetics such as lignocaine and/or prilocaine as a cream, gel, or spray is well established and is moderately effective in retarding ejaculation [33,[91][92][93][94][95][96][97][98][99][100][101][102]. However, unless a condom is used, their use may be associated with significant penile hypoanesthesia and vaginal numbness, and resultant female anorgasmia.…”

Section: Topical Anestheticsmentioning

confidence: 99%

Disorders of Orgasm and Ejaculation in Men

Rowland

McMahon

Abdo

et al. 2010

The Journal of Sexual Medicine

305

248

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Introduction Ejaculatory/orgasmic disorders are common male sexual dysfunctions, and include premature ejaculation (PE), inhibited ejaculation, anejaculation, retrograde ejaculation, and anorgasmia. Aim To provide recommendations and guidelines concerning current state-of-the-art knowledge for management of ejaculation/orgasmic disorders in men. Methods An international consultation in collaboration with the major urology and sexual medicine associations assembled over 200 multidisciplinary experts from 60 countries into 25 committees. Committee members established specific objectives and scopes for various male and female sexual medicine topics. The recommendations concerning state-of-the-art knowledge of disorders of orgasm and ejaculation represent the opinion of seven experts from seven countries developed in a process over a 2-year period. Main Outcome Measure Expert opinion was based on grading of evidence-based medical literature, widespread internal committee discussion, public presentation and debate. Results Premature ejaculation management is largely dependent upon etiology. Lifelong PE is best managed with PE pharmacotherapy (selective serotonin re-uptake inhibitor [SSRI] and/or topical anesthetics). The management of acquired PE is etiology specific and may include erectile dysfunction (ED) pharmacotherapy in men with comorbid ED. Behavioral therapy is indicated when psychogenic or relationship factors are present and is often best combined with PE pharmacotherapy in an integrated treatment program. Retrograde ejaculation is managed by education, patient reassurance, pharmacotherapy, or bladder neck reconstruction. Delayed ejaculation, anejaculation, and/or anorgasmia may have a biogenic and/or psychogenic atiology. Men with age-related penile hypoanesthesia should be educated, reassured, and instructed in revised sexual techniques which maximize arousal. Conclusions Additional research is required to further the understanding of the disorders of ejaculation and orgasm.

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“…Diffusion of residual topical anesthetic on the penis into the vaginal wall also may result in numbness in the partner. [19] Topical anesthetics are contraindicated in patients who are either allergic themselves or have partners who are allergic to any component of the product.…”

Section: Management Planmentioning

confidence: 99%

Premature ejaculation: A review

Gajjala

Khalidi

2014

Indian J Sex Transm Dis

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Premature ejaculation (PE) is a common male sexual disorder. It is defined by the Diagnostic and statistical manual of mental disorders as “ejaculation occurring, without control, on or shortly after penetration and before the person wishes it, causing marked distress or interpersonal difficulty.[1] Although the timing of intravaginal ejaculatory latency time (IELT) (i.e., time from penetration to ejaculation) is not included in this definition, an IELT of <2 min, or ejaculation occurring before penetration, has been considered consistent with PE.[2] Management involves both the patient and his partner. Therapeutic options should suit both partners and be appropriate to their habit in planning and frequency of intercourse. Follow-up at appropriate intervals to judge efficacy, titrate dosage of pharmacological treatments and ascertain side effects is mandatory.

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Re: Efficacy of Prilocaine-Lidocaine Cream in the Treatment of Premature Ejaculation

Cited by 16 publications

References 0 publications

Comparison of Alpha Blockers in Treatment of Premature Ejaculation: A Pilot Clinical Trial

Comparison of Alpha Blockers in Treatment of Premature Ejaculation: A Pilot Clinical Trial

Disorders of Orgasm and Ejaculation in Men

Premature ejaculation: A review

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