Re-emergence of  Chlamydia trachomatis  infection after mass antibiotic treatment of a trachoma-endemic Gambian community: a longitudinal study

Burton, Matthew J.; Holland, Martin J.; Makalo, Pateh; Aryee, Esther A. N.; Alexander, Neal; Sillah, Ansumana; Faal, Hannah; West, Sheila K.; Foster, Allen; Johnson, Gordon J.; Mabey, David; Bailey, Robin L.

doi:10.1016/s0140-6736(05)61029-x

Cited by 136 publications

(149 citation statements)

References 15 publications

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“…The sequence analysis of ompA of these strains revealed a single-nucleotide difference from the D and H genotypes, but they were identical to the ompA sequence of serovars B and Ba over the remainder of the gene. The conclusion was that these appeared to be true genital strains that had acquired an ocular MOMP sequence (9). The tarP sequence is consistent with this assumption.…”

Section: Discussionmentioning

confidence: 54%

“…The clinical isolates used in this study are listed in Table 1. Ocular, genital, urethral, and anorectal swabs from male and female patients were obtained as previously described (7,9,18,21,28,34,54,62,67) and used for the PCR amplification of tarP. Sequences analyzed in this study were derived from specimens obtained at clinical sites in the North Bank, Lower River, Central River, and Upper River Regions, The Gambia; Nairobi, Kenya; Rombo District, Tanzania; Winnipeg, Manitoba, Canada; Ottawa, Ontario, Canada; Indianapolis, IN; San Francisco, CA; Seattle, WA; and Northern Territory, Australia.…”

Section: Methodsmentioning

confidence: 99%

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Phylogenetic Analysis ofChlamydia trachomatisTarp and Correlation with Clinical Phenotype

et al. 2010

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Chlamydia trachomatis is the leading cause of infectious blindness worldwide and is the most commonly reported pathogen causing sexually transmitted infections. Tarp (translocated actin recruiting phosphoprotein), a type III secreted effector that mediates actin nucleation, is central to C. trachomatis infection. The phylogenetic analysis of tarP from reference strains as well as ocular, genital, and lymphogranuloma venereum (LGV) clinical isolates demonstrated an evolutionary relationship with disease phenotype, with LGV and ocular isolates branched into clades that were separate from the urogenital isolates. The sequence analysis of Tarp indicated a high degree of variability and identified trends within clinical groupings. Tarps from LGV strains contained the highest number of tyrosine-rich repeat regions (up to nine) and the fewest (two) predicted actin binding domains. The converse was noted for Tarp proteins from ocular isolates that contained up to four actin binding domains and as few as one tyrosine-rich repeat region. The results suggest that Tarp is among the few known genes to play a role in C. trachomatis adaptations to specific niches within the host.

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Section: Discussionmentioning

confidence: 54%

Section: Methodsmentioning

confidence: 99%

Phylogenetic Analysis ofChlamydia trachomatisTarp and Correlation with Clinical Phenotype

et al. 2010

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“…4 However, evidence from the Gambia and the United Republic of Tanzania indicates that three rounds are unnecessary in low prevalence settings. [5][6][7][8] In such situations, repeated azithromycin MDA may be detrimental if it results in the selection of macrolideresistant pathogens. Although currently there is no evidence that repeated MDA increases the prevalence of azithromycinresistant C. trachomatis, 9 there is epidemiological evidence suggesting that pharyngeal carriage of macrolide-resistant Streptococcus pneumoniae increases following repeated MDA for trachoma control.…”

Section: Introductionmentioning

confidence: 99%

Mass administration of azithromycin andStreptococcus pneumoniaecarriage: cross-sectional surveys in the Gambia

Burr

Milne

Jafali

et al. 2014

Bull. World Health Organ.

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“…Despite the limited evidence in randomized trials, the overwhelming evidence from cohort studies, the rate of clinical disease and infection rates fall after the mass distribution of antibiotics (39)(40)(41)(42)(43). The mass distribution is indicated when the proportion of children aged 1-9 years with follicular trachoma (TF) is more than 10% in assessed community.…”

Section: Treatmentmentioning

confidence: 99%

Trachoma as cause of blindness: literature review

Silva¹,

Andrade²,

Oliveira³

et al. 2017

int arch med

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This is a literature review that used as database articles in websites like Bireme, SciELO, LILACS, Journals and Webartigos. Development:Trachoma is an ocular inflammatory disease, whose etiological agent is Chlamydia trachomatis, which affects the conjunctiva and cornea causing a chronic relapsing keratoconjunctivitis, in the course of time may lead to the formation of entropion, trichiasis and possible blindness. Its transmission occurs in the home environment, directly or indirectly. The occurrence of trachoma is mostly where hygiene and lifestyle habits are precarious. According to the World Health Organization, there are six million people currently infected.

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Re-emergence of Chlamydia trachomatis infection after mass antibiotic treatment of a trachoma-endemic Gambian community: a longitudinal study

Cited by 136 publications

References 15 publications

Phylogenetic Analysis ofChlamydia trachomatisTarp and Correlation with Clinical Phenotype

Phylogenetic Analysis ofChlamydia trachomatisTarp and Correlation with Clinical Phenotype

Mass administration of azithromycin andStreptococcus pneumoniaecarriage: cross-sectional surveys in the Gambia

Trachoma as cause of blindness: literature review

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