Re-emergence of T lymphocyte-mediated synaptopathy in progressive multiple sclerosis
Krizia Sanna,
Antonio Bruno,
Sara Balletta
et al.
Abstract:BackgroundSecondary progressive multiple sclerosis (SPMS) is defined by the irreversible accumulation of disability following a relapsing-remitting MS (RRMS) course. Despite treatments advances, a reliable tool able to capture the transition from RRMS to SPMS is lacking. A T cell chimeric MS model demonstrated that T cells derived from relapsing patients exacerbate excitatory transmission of central neurons, a synaptotoxic event absent during remitting stages. We hypothesized the re-emergence of T cell synapto… Show more
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