Re‐emergent tremor in Parkinson's disease: the effect of dopaminergic treatment

Belvisi, Daniele; Conte, Antonella; Cutrona, Carolina; Costanzo, Matteo; Ferrazzano, Gina; Fabbrini, Giovanni; Berardelli, Alfredo

doi:10.1111/ene.13619

Cited by 19 publications

(19 citation statements)

References 25 publications

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“…4 While based on appendicular rather than oculomotor data, a similar neural mechanism may account for the sequence effect in voluntary self-paced saccades in PD, although other mechanisms involving omnipause neurons or direct effects on the superior colliculus are possible. 5 In summary, our data suggest that saccadic bradykinesia can be elicited at the bedside (here also documented formally using VNG) and was apparent in all consecutive patients but absent in age-matched controls. "Saccadic bradykinesia" may be a useful and early clinical sign of PD, but future studies should confirm these findings and assess its specificity as a clinical biomarker of disease progression.…”

Section: Saccadic Bradykinesia In Parkinson's Disease: Preliminary Observationssupporting

confidence: 59%

“…Re‐emergent tremor and resting tremor have been hypothesized to be a continuum (“tremor of stability”), 2 and they share clinical features. 5 However, re‐emergent tremor has as smaller dopamine response and slightly higher frequency than rest tremor. 4 Our data suggest that these differences may be explained by the cerebellum, which comes in with voluntary movement and transiently modulates the tremor oscillator and possibly tremor frequency, while the fundamental character of the tremor remains unchanged.…”

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confidence: 99%

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Cerebello‐Cortical Control of Tremor Rhythm and Amplitude in Parkinson's Disease

et al. 2021

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Section: Saccadic Bradykinesia In Parkinson's Disease: Preliminary Observationssupporting

confidence: 59%

mentioning

confidence: 99%

Cerebello‐Cortical Control of Tremor Rhythm and Amplitude in Parkinson's Disease

et al. 2021

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“…[1][2][3] Clinical observations suggest that RET may have mechanisms similar to rest tremor. 2,[4][5][6][7] Only 1 study investigated RET pathophysiology and found that a network converging on the sensorimotor cortex could participate in RET. 8 A better understanding of RET pathophysiology may open up therapeutic strategies for a type of tremor that is often more disabling than rest tremor.…”

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confidence: 99%

Re‐emergent Tremor in Parkinson's Disease: The Role of the Motor Cortex

et al. 2020

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Background: Parkinson's disease patients may show a tremor that appears after a variable delay while the arms are kept outstretched (re-emergent tremor). The objectives of this study were to investigate re-emergent tremor pathophysiology by studying the role of the primary motor cortex in this tremor and making a comparison with rest tremor. Methods:We enrolled 10 Parkinson's disease patients with both re-emergent and rest tremor. Tremor was assessed by spectral analysis, corticomuscular coherence and tremor-resetting produced by transcranial magnetic stimulation over the primary motor cortex. We also recorded transcranial magnetic stimulation-evoked potentials generated by motor cortex stimulation during rest tremor, tremor suppression during wrist extension, and re-emergent tremor. Spectral analysis, corticomuscular coherence, and tremor resetting were compared between re-emergent tremor and rest tremor.Results: Re-emergent tremor showed significant corticomuscular coherence, causal relation between motor cortex activity and tremor muscle and tremor resetting. The P60 component of transcranial magnetic stimulation-evoked potentials reduced in amplitude during tremor suppression, recovered before re-emergent tremor, was facilitated at re-emergent tremor onset, and returned to values similar to those of rest tremor during re-emergent tremor. Compared with rest tremor, re-emergent tremor showed similar corticomuscular coherence and tremor resetting, but slightly higher frequency. Conclusions:Re-emergent tremor is causally related with the activity of the primary motor cortex, which is likely a convergence node in the network that generates re-emergent tremor.

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“…An EMG study exploring the nature of postural tremor in PD revealed two pathophysiologically distinct clusters: 81% had re-emergent tremor and 19% had a pure postural tremor ( 111 ). The exact neural correlates of re-emergent tremor remain elusive; however, there is evidence to suggest that it overlaps with parkinsonian rest tremor in terms of frequency (both are of 3–5 Hz), the direction of movement (occasional supination-pronation), and response to dopaminergic medications ( 106 , 111 , 112 ). A recent study based on transcranial magnetic stimulation demonstrated that re-emergent tremor and rest tremor have common pathophysiological mechanisms in which the motor cortex plays an important role ( 113 ).…”

Section: Tremor In the Setting Additional Neurological Featuresmentioning

confidence: 99%

Tremor Syndromes: An Updated Review

Lenka

Jankovic

2021

Front. Neurol.

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Tremor is the most commonly encountered movement disorder in clinical practice. A wide range of pathologies may manifest with tremor either as a presenting or predominant symptom. Considering the marked etiological and phenomenological heterogeneity, it would be desirable to develop a classification of tremors that reflects their underlying pathophysiology. The tremor task force of the International Parkinson Disease and Movement Disorders Society has worked toward this goal and proposed a new classification system. This system has remained a prime topic of scientific communications on tremor in recent times. The new classification is based on two axes: 1. based on the clinical features, history, and tremor characteristics and 2. based on the etiology of tremor. In this article, we discuss the key aspects of the new classification, review various tremor syndromes, highlight some of the controversies in the field of tremor, and share the potential future perspectives.

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Re‐emergent tremor in Parkinson's disease: the effect of dopaminergic treatment

Abstract: Dopaminergic treatment modified RET occurrence, severity and body distribution. Dopaminergic depletion plays a role in the pathophysiology of RET.

Cited by 19 publications

References 25 publications

Cerebello‐Cortical Control of Tremor Rhythm and Amplitude in Parkinson's Disease

Cerebello‐Cortical Control of Tremor Rhythm and Amplitude in Parkinson's Disease

Re‐emergent Tremor in Parkinson's Disease: The Role of the Motor Cortex

Tremor Syndromes: An Updated Review

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