Re-evaluation of inhibin α subunit as a tumour suppressor in prostate cancer

Risbridger, Gail P.; Ball, Emma M A; Wang, Hong; Mellor, Sally Louise; Peehl, Donna M.

doi:10.1016/j.mce.2004.02.015

Cited by 31 publications

(19 citation statements)

References 11 publications

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“…Notably, TGF-β has been recognized as a tumour suppressor in premalignant stages of carcinogenesis with an additional dual role as a pro-oncogene in later stages of the disease, leading to metastasis (19,32). Regarding metastasis, inhibition of TGF-β suppresses experimental metastasis to multiple organs (33,34).…”

Section: Discussionmentioning

confidence: 99%

Inhibin-α subunit in normal and malignant human cervical tissue and cervical cancer cell lines

Mylonas

Dian²

2011

Oncol Rep

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Abstract. Inhibins are dimeric glycoproteins composed of an α-subunit and one of two possible β-subunits (βA or βB), with substantial roles in human reproduction and in endocrineresponsive tumours. Four normal cervical tissue samples together with 10 specimens of well-differentiated squamous cervical cancer and adenocarcinoma of the cervix were immunohistochemically analysed for the expression of the inhibin-α subunit. Additionally, two cervical carcinoma cell lines (HeLa and CaSKi) were analysed with immunofluorescence and RT-PCR for the expression of the inhibin-α subunit. We demonstrated for the first time an immunolabelling of the inhibin-α subunit in normal and malignant cervical tissue, as well as cervical cancer cells. However, the immunoreactive reaction was albeit weak and mostly confined to mitotic cells in the analysed cervical tissues. Additionally, the expression pattern of this subunit was rather inconsistent. Therefore, the immunohistochemical evaluation of this subunit in cervical tissue cannot be used as a prognostic marker as suggested for endometrial cancer. However, since the expression of the inhibin-α subunit is minimal in HeLa cells as assessed by immunofluorescence and RT-PCR, the CaSKi cell line might be a better model for further functional experiments regarding cervical pathogenesis.

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Section: Discussionmentioning

confidence: 99%

Inhibin-α subunit in normal and malignant human cervical tissue and cervical cancer cell lines

Mylonas

Dian²

2011

Oncol Rep

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“…However, it not clear whether these experimental findings offer insight into the pathogenesis of TGCT, given that such stromal tumors do not arise from germ cells. INHA inactivation has also been found to be a common event in prostate cancer cells (20,21), although there is also evidence suggesting that the a subunit is expressed in advanced tumors (22).…”

Section: Discussionmentioning

confidence: 99%

Genetic Variation in the Inhibin Pathway and Risk of Testicular Germ Cell Tumors

et al. 2008

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Gene-knockout studies in mice suggest that INHA, encoding a subunit of gonadotropin-regulating proteins known as inhibins, is a tumor suppressor for testicular stromal cell tumors. It is not known whether genetic variation in the inhibin pathway also influences susceptibility to testicular germ cell tumors (TGCT), the most common testicular cancer in young men. To address this question, we conducted a case-control analysis (577 cases; 707 controls) of single-nucleotide polymorphisms (SNP) in genes in the inhibin pathway among participants in the U.S. Servicemen's Testicular Tumor Environmental and Endocrine Determinants Study. Thirty-eight tagging SNPs in six genes (INHA, INHBA, INHBB, INHBC, INHBE, and SMAD4) were genotyped. Odds ratios (OR) and 95% confidence intervals (CI) relating variant genotypes to TGCT risk were calculated using unconditional logistic regression. Among White subjects, an elevated risk of TGCT was observed for carriers of the T allele of the INHA variant rs2059693 (CT genotype: OR, 1.33; 95% CI, 1.04-1.71; TT: OR, 1.60; 95% CI, 1.01-2.52; P trend = 0.008). The association with rs2059693 was stronger for nonseminomas, and for teratomas and teratocarcinomas in particular (N = 58; CT: OR, 1.63; 95% CI, 0.89-2.99; TT: OR, 4.54; 95% CI 2.00-10.3; P trend = 0.0008). We found no evidence of association with variants in the other investigated genes. These findings suggest that genetic variation in the INHA locus influences TGCT development.

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“…To reduce wastage of precious human prostate tissues it was decided to use a cohort of patient tissues that have already being evaluated for clinicopathological characteristics, VEGF-C expression and LVD (using D2-40) (1, 9) by our collaborating investigator; Elizabeth Williams. A number of independent studies have shown increases in INHA expression to be associated with PCa progression (10,11). To determine if INHA expression can be correlated to lymph node status we used tissues from a cohort of PCa patients who had organ-confined disease and those who had lymph node metastasis.…”

Section: Bodymentioning

confidence: 99%

New Action of Inhibin Alpha Subunit in Advanced Prostate Cancer

Balanathan¹

2008

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Re-evaluation of inhibin α subunit as a tumour suppressor in prostate cancer

Cited by 31 publications

References 11 publications

Inhibin-α subunit in normal and malignant human cervical tissue and cervical cancer cell lines

Inhibin-α subunit in normal and malignant human cervical tissue and cervical cancer cell lines

Genetic Variation in the Inhibin Pathway and Risk of Testicular Germ Cell Tumors

New Action of Inhibin Alpha Subunit in Advanced Prostate Cancer

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