Re-evaluation of the reliability of pharmacologic and cold pressor studies in hypertension and pheochromocytoma

Two‐Week Test–Retest Stability of the Cold Pressor Task Procedure at two different Temperatures as a Measure of Pain Threshold and Tolerance

“…The stability of vascular and myocardial response patterns provoked by the CPT as clinically indicative test has already been investigated in several studies . Results show that the responses elicited by the CPT are reliable and show little evidence of attenuation over the test–retest interval, indicating that reactivity to the CPT can be reliably assessed over a 2‐week interval (Saab et al …”

The Treatment of Severe Hypertension

“…This was the use of histamine (Roth and Kvale, 1945). During the next few years a series of such tests became popular (Entwisle et al, 1951 ;Evans et al, 1951). Some drugs, such as histamine, mecholyl, and tetraethyl ammonium salts, provoke a hypertensive crisis by direct or reflex stimulation of the adrenals with liberation of adrenaline and noradrenaline.…”