Re-expression of microRNA-4319 inhibits growth of prostate cancer via Her-2 suppression

Lin, Xiaohui; Wang, Y.

doi:10.1007/s12094-018-1871-y

Cited by 31 publications

(26 citation statements)

References 24 publications

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“…In this study, miR-4319 was predicted to possess binding capacity with circATXN7 through bioinformatics website, and then validated to bind with circATXN7 in GC cells. The suppressive function of miR-4319 on the development of prostate cancer [29] and breast cancer [30] has been uncovered, but the specific role of miR-4319 in GC and the effect that the interaction of circATXN7 with miR-4319 on GC progression remain unclear. In this research, a low level of miR-4319 was detected in GC tissues and cells.…”

Section: Discussionmentioning

confidence: 99%

Circular RNA ATXN7 promotes the development of gastric cancer through sponging miR-4319 and regulating ENTPD4

Zhang

Chen

et al. 2020

Cancer Cell Int

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Background: Circular RNAs (circRNAs) which are shown as a class of RNAs exhibit the importance in the regulation of gene expression and the development of biological process. However, the expression profile and molecular mechanism of circRNA ATXN7 (circATXN7) is still mostly uncertain in gastric cancer (GC). Methods: qRT-PCR analysis was performed to detect the expression of circATXN7, miR-4319 and ENTPD4 in GC tissues and cells. CCK-8, colony formation, EdU, flow cytometry, TUNEL and transwell assays were conducted to assess the effect of circATXN7 or miR-4319 on cell proliferation, apoptosis and invasion. In vivo assays were utilized to further analyze the function of circATXN7 on the tumorigenesis and progression of GC. The interaction between miR-4319 and circATXN7 (or ENTPD4) was verified using luciferase reporter and RNA pull-down assays. Results: The results showed an upregulated circATXN7 expression in GC tissues and cell lines. Besides, silenced circATXN7 hampered the proliferation and invasion as well as promoted the apoptosis in GC cells. Moreover, low expression of miR-4319 was found in GC. It was determined that circATXN7 acted as a sponge for miR-4319 and had a negative association with miR-4319. We also found that miR-4319 upregulation restrained GC cell proliferation and migration whereas enhanced apoptosis. Subsequently, ENTPD4, the target gene of miR-4319, was found overexpressed in GC. Additionally, it was negatively correlated with miR-4319 whereas positively associated with circATXN7. In vivo experiments, circATXN7 silence was confirmed to inhibit GC tumor growth. Conclusions: CircATXN7 promoted GC development through sponging miR-4319 and regulating ENTPD4, which identified circATXN7 as a new biomarker in GC.

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Section: Discussionmentioning

confidence: 99%

Circular RNA ATXN7 promotes the development of gastric cancer through sponging miR-4319 and regulating ENTPD4

Zhang

Chen

et al. 2020

Cancer Cell Int

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“…MicroRNAs (miRNAs) are a kind of small noncoding RNAs about 22 nucleotides long, which function as oncogenes or cancer‐suppressor genes in a wide spectrum of cancers . Overexpression of miRNA‐4319 hinders prostate cancer cell proliferation through inhibition of HER‐2 expression . Circular RNA circ‐BANP modulates miR‐503/LARP1 signaling to drive lung cancer development .…”

Section: Introductionmentioning

confidence: 99%

LncRNA TTN‐AS1 drives invasion and migration of lung adenocarcinoma cells via modulation of miR‐4677‐3p/ZEB1 axis

Zhong

Wang

et al. 2019

J of Cellular Biochemistry

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Lung adenocarcinoma is the most prevalent type of lung cancer with a high incidence and mortality worldwide. Metastasis is the major cause of high death rate in lung cancer and the potential mechanism of lung adenocarcinoma metastasis remains indistinct. Emerging investigations have demonstrated that long noncoding RNA is a kind of non–protein coding RNA and plays a critical role in cancer progression and metastasis. TTN antisense RNA 1 (TTN‐AS1) has been reported to promote cell growth and metastasis in cancer. However, the function of TTN‐AS1 in lung adenocarcinoma is still to be illustrated. In this study, we observed that TTN‐AS1 was upregulated in tissues and cells of lung adenocarcinoma and associated with poor overall survival. TTN‐AS1 promoted cell proliferation, migration, invasion, and epithelial‐mesenchymal transition in lung cancer. TTN‐AS1 directly bound with miR‐4677‐3p and negatively regulated miR‐4677‐3p. MiR‐4677‐3p rescued the inhibitive impacts of TTN‐AS1 knockdown on lung adenocarcinoma. Furthermore, zinc finger E‐box binding homeobox 1 (ZEB1) was the target of miR‐4677‐3p, and TTN‐AS1 modulated ZEB1 by competing for miR‐4677‐3p. TTN‐AS1 drove the invasion and migration of lung adenocarcinoma cells by targeting the miR‐4677‐3p/ZEB1 axis. To sum up, our study offers insights into the mechanism of TTN‐AS1 in lung adenocarcinoma metastasis and targeting the TTN‐AS1/miR‐4677‐3p/ZEB1 axis may be the potential innovate therapeutic strategy for the patients with lung adenocarcinoma.

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“…Increasing studies focus on the function and underlying mechanism of long non‐coding RNA (lncRNA) in human tumors . As a member of non‐coding RNA (ncRNA) family, lncRNA is defined as the RNA transcripts with a length > 200 nucleotides, which is differentiated from other ncRNAs, such as microRNA and transfer RNA . In general, lncRNA is classified into five groups based on the different gene locations, including antisense lncRNA, intronic transcript, large intergenic noncoding RNA, promoter‐associated lncRNA and UTR associated lncRNA .…”

Section: Introductionmentioning

confidence: 99%

“…[7][8][9] As a member of non-coding RNA (ncRNA) family, lncRNA is defined as the RNA transcripts with a length > 200 nucleotides, which is differentiated from other ncRNAs, such as microRNA and transfer RNA. [10][11][12][13][14] In general, lncRNA is classified into five groups based on the different gene locations, including antisense lncRNA, intronic transcript, large intergenic noncoding RNA, promoter-associated lncRNA and UTR associated lncRNA. 15 Of these five groups, antisense lncRNA, a type of endogenous lncRNA complementary to the corresponding transcription sequence, comprises 50-70% of all lncRNA.…”

Section: Introductionmentioning

confidence: 99%

ELK1‐activated GPC3‐AS1/GPC3 axis promotes the proliferation and migration of cervical cancer cells

Zhu

2019

The Journal of Gene Medicine

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Background Long non‐coding RNA (lncRNA) is reported to be involved in multiple biological processes in numerous human tumors. Furthermore, an increasing number of studies have confirmed the involvement of lncRNA in the initiation and development of human cancers, including cervical cancer (CC). Methods The present study explored the potential role of lncRNA glypican 3 antisense transcript 1 (GPC3‐AS1) with respect to regulating CC cell proliferation and migration. Results A quantitative reverse transcriptase‐polymerase chain reaction confirmed that GPC3‐AS1 was up‐regulated in CC cells compared to normal CRL‐2614 cells. Loss‐of‐function assays demonstrated the negative effect of GPC3‐AS1 depletion on CC cell proliferation and migration. GPC3‐AS1 positively regulated its nearby gene glypican 3 (GPC3). Significant up‐regulation of GPC3 was also observed in CC cells, consistently with GPC3‐AS1. In addition, GPC3‐AS1 and GPC3 synergistically promoted the proliferative and migratory abilities of CC cells. Mechanistic investigation showed that ELK1 acted as the transcription activator of GPC3‐AS1 and GPC3, thus contributing to their up‐regulation in CC cells. Rescue assays indicated that the ELK1‐induced GPC3‐AS1/GPC3 axis promoted cell proliferation and migration in CC. Conclusions The results of the present study have revealed a novel molecular pathway that can regulate CC cell proliferation and migration, thus providing a new basis for investigating the molecular mechanism associated with CC progression.

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Re-expression of microRNA-4319 inhibits growth of prostate cancer via Her-2 suppression

Abstract: The growth and chemo-resistance of PC cells may be suppressed via re-expression of miR-4319 that inhibits Her-2 signaling.

Cited by 31 publications

References 24 publications

Circular RNA ATXN7 promotes the development of gastric cancer through sponging miR-4319 and regulating ENTPD4

Circular RNA ATXN7 promotes the development of gastric cancer through sponging miR-4319 and regulating ENTPD4

LncRNA TTN‐AS1 drives invasion and migration of lung adenocarcinoma cells via modulation of miR‐4677‐3p/ZEB1 axis

ELK1‐activated GPC3‐AS1/GPC3 axis promotes the proliferation and migration of cervical cancer cells

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