Re: Focal Liver 18F-FDG Uptake in a Patient Who Underwent Thrombolysis for Brachiocephalic and Subclavian Thrombosis: A Potential Pitfall

Chan, Tak Kwong; Kung, Boom Ting; Yong, Ting Kun Au; Ng, Koon Kiu; Hui, Yan

doi:10.1097/rlu.0000000000004042

Clin Nucl Med

2022

DOI: 10.1097/rlu.0000000000004042

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Re: Focal Liver 18F-FDG Uptake in a Patient Who Underwent Thrombolysis for Brachiocephalic and Subclavian Thrombosis: A Potential Pitfall

Tak Kwong Chan

Boom Ting Kung

Ting Kun Au Yong

et al.

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2023

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“…The third inflow system may cause focal contrast enhancement or radiotracer uptake on imaging, which can be misinterpreted as a neoplastic entity 7 . 18 F-FDG uptake in the liver secondary to vascular obstruction is well known 8–10 . No vascular obstruction was identified in any of the presented cases.…”

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confidence: 55%

“…7 18 F-FDG uptake in the liver secondary to vascular obstruction is well known. [8][9][10] No vascular obstruction was identified in any of the presented cases. These cases of artifactual focal hepatic avidity on PSMA PET are useful to raise awareness of their likelihood and their potential to cause image misinterpretation leading to unwanted PCa treatment escalation or denying patients therapy with curative intent.…”

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confidence: 60%

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Aberrant Vascular Anatomy Associated With Artifactual Focal Avidity in the Liver on PSMA PET

et al. 2023

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68Ga–prostate-specific membrane antigen (PSMA) PET/CT is a valuable tool for staging and restaging of prostate cancer. Prostate-specific membrane antigen expression is not specific to prostate cancer, as it is expressed in normal tissues as well as in neoplastic and nonneoplastic processes. Awareness of the broad possibility of lesions with PSMA avidity is necessary to recognize normal variants and avoid potential pitfalls in image interpretation. We present a series of cases showing physiologic focal PSMA avidity in hepatic segment IVb. We correlate this uptake with aberrant hepatic vasculature. The awareness of this variant is important for accurate image interpretation to prevent additional invasive procedures, undue treatment escalation, and denial of curative treatment to patients.

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confidence: 55%

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Aberrant Vascular Anatomy Associated With Artifactual Focal Avidity in the Liver on PSMA PET

et al. 2023

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