Re: Helicobacter Pylori Infection and Colorectal Cancer Risk: Evidence From a Large Population-Based Case-Control Study in Germany

Kapetanakis, Nikolaos; Kountouras, Jannis; Zavos, Christos; Michael, Stavros; Tsarouchas, G.; Gavalas, Emmanuel; Anastasiadou, Kyriaki; Tsiaousi, Elena; Venizelos, Ioannis; Nikolaidou, Christina; Vardaka, Elisabeth; Kouklakis, George; Moschos, I

doi:10.1093/aje/kws302

Cited by 23 publications

(16 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Except for intragastric malignancy disease, many scientists have noted that this bacterium is also related to colon neoplasms and colorectal carcinoma (CRC) formation and have shown that infection with H. pylori confers a 1.3-1.97-fold increased risk of colon adenoma or adenoma with high-grade dysplasia in the past two decades [3][4][5]. However, some Asian studies did not show consistent results.…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori infection and increased diabetes prevalence were the risks of colorectal adenoma: a systematic review and meta-analysis

Wang

Lin

Chen

et al. 2019

Preprint

View full text Add to dashboard Cite

Background Helicobacter pylori (H. Pylori) infection and hyperglycemia may be associated with an increased risk of colorectal neoplasm. However these two factors affect colorectal neoplasm remain controversial. We aimed to carry out a meta-analysis to evaluate the study population diabetes prevalence rate and H. pylori infection rate with colorectal adenoma risk. Methods We conducted a systemic research through English databases for medical reports. We also recorded the diabetes prevalence and H. pylori infection prevalence in each study. We classified these studies into 4 subgroups as their background population diabetes prevalence < 6%(Group 1); between 6 to 8%(Group 2); between 8 to 10 %(Group 3) and more than 10%(Group 4). The random effects model had used to calculate pooled prevalence estimates with 95% confidence interval [CI]. Results Twenty seven studies were finally eligible for meta-analysis. The random-effects model of meta-analysis was chosen, showing pooled odds ratio (OR) equal to 1.51 (95 % CI 1.39–1.63). The subgroup meta-analyses showed in Group 1 the H. pylori infection associated colorectal adenoma risk OR was 1.24 (95 % CI 0.86–1.78). As diabetes rate exceed 6%, the H. pylori infection became more significant increased risk of colorectal adenoma (Group 2: OR 2.16 (95 % CI 1.61–2.91); Group 3: OR 1.40 (95 % CI 1.24–1.57); Group 4: OR 1.52 (95 % CI 1.46–1.57)). Conclusions The results of this meta-analysis showed DM prevalence would affect the risk factor of colorectal adenoma with H. pylori infection.

show abstract

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori infection and increased diabetes prevalence were the risks of colorectal adenoma: a systematic review and meta-analysis

Wang

Lin

Chen

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…Remarkably, the serologic test does not discriminate between current and past infections and, apart from past infections that may even be more relevant for oncogenesis, such a distinction is essential because only current H. pylori infection (Hp-I) induces humoral and cellular immune responses that produce or perpetuate chronic inflammatory processes in gastrointestinal tract with potential oncogenic sequelae; many neoplasms including colorectal neoplasms arise at the sites of chronic inflammation and infection (2,3).…”

mentioning

confidence: 99%

Helicobacter pylori and Colorectal Cancer Risk—Letter

Kountouras

Kapetanakis

Zavos

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

Epplein and colleagues (1) reported that the overall Helicobacter pylori (H. pylori) seropositivity was not associated with colorectal cancer risk, and seropositivity to specific H. pylori proteins, particularly the toxin VacA antibodies, may be associated with a higher risk of colorectal cancer and right-sided colon cancers.Remarkably, the serologic test does not discriminate between current and past infections and, apart from past infections that may even be more relevant for oncogenesis, such a distinction is essential because only current H. pylori infection (Hp-I) induces humoral and cellular immune responses that produce or perpetuate chronic inflammatory processes in gastrointestinal tract with potential oncogenic sequelae; many neoplasms including colorectal neoplasms arise at the sites of chronic inflammation and infection (2, 3).On the basis of histology for documentation of current Hp-I, our series in 50 patients with colorectal cancer, 25 patients with colorectal adenomas, and 10 controls showed significantly higher Hp-I presence in colorectal adenomas (68%) and colorectal cancer (84%) groups than controls (30%; ref. 4). Remarkably, H. pylori presence was documented by immunohistochemical stain in colorectal adenomas and colorectal cancer tissues (4, 5).Presence of Hp-I with accompanying immunohistochemical expression of CD44 [indicator of cancer stem cells (CSC) and/or bone marrow-derived stem cells (BMDSC)] in biopsy specimens was found in a high proportion of patients with colorectal adenomas accompanied with moderate/severe dysplasia (88%) and patients with colorectal cancer with moderate/severe degree of malignancy (91%). Comparable pictures were also obtained for proliferation marker Ki-67, antiapoptotic Bcl-2, and CD45 (assessing mainly T and B lymphocytes locally) immunohistochemical expressions (4, 5); these mediators might also serve as a risk H. pylori biomarkers involved in the sequence: normal colon epithelium-colorectal adenomas-colorectal cancer development/progression.Considering the mechanisms underlying the Hp-I involvement in the aforementioned sequence, apart from the left colon-limited oncogenic actions of Hp-induced gastrin, also mentioned by Epplein and colleagues (1), our studies indicate that Hp-I may be involved in colon carcinogenesis by: (i) inducing a possible chronic inflammatory mucosal damage, comparable with upper gastrointestinal tract (UGT); (ii) stimulating CSCs or recruiting BMDSCs, similar to UGT Hp-I-associated chronic inflammation, metaplasia, dysplasia, and BMDSCs recruitment that may facilitate tumor formation/progression in animal models and humans; (iii) and affecting oncogenes and immune surveillance processes (4, 5).Finally, the following concept about the VacA antibody association with right-sided colon cancers observed by Epplein and colleagues (1) might be considered: (i) as right-sided colon cancers have higher distant metastases than left-sided colon cancers, circulation of activated monocytes (possibly infected with H. pylori due to defective autoph...

show abstract

“…3 Recent data also indicate a serologic association between H pylori infection and the risk of colorectal adenoma (CRA) and CRC. 4,5 However, the serologic measurement of infection status is less than perfect. 4 Based on histology, the criterion standard for current H pylori diagnosis, our data from 50 CRC patients, 25 CRA patients, and 10 control individuals showed a significantly higher presence of H pylori in the CRA (68%) and CRC (84%) groups than in the control group (30%) 5,6 ; the presence of H pylori was documented by immunohistochemical stain.…”

mentioning

confidence: 99%

Percutaneous placement of a biliary self-expandable metallic stent for severe post-ERCP bleeding

Ödemiş¹,

Shorbagi

Yurdakul

et al. 2014

Gastrointestinal Endoscopy

View full text Add to dashboard Cite

Re: Helicobacter Pylori Infection and Colorectal Cancer Risk: Evidence From a Large Population-Based Case-Control Study in Germany

Cited by 23 publications

References 4 publications

Helicobacter pylori infection and increased diabetes prevalence were the risks of colorectal adenoma: a systematic review and meta-analysis

Helicobacter pylori infection and increased diabetes prevalence were the risks of colorectal adenoma: a systematic review and meta-analysis

Helicobacter pylori and Colorectal Cancer Risk—Letter

Percutaneous placement of a biliary self-expandable metallic stent for severe post-ERCP bleeding

Contact Info

Product

Resources

About