Re-Irradiation for Recurrent Head and Neck Cancer: Freedom from Cancer Recurrence Rate

Mohamad, Issa; Hejleh, Taher Abu; Abdelqader, Sania; Wahbeh, Lina; Taqash, Ayat; Almousa, Abdelatif; Mayta, Ebrahim; Al‐Ibraheem, Akram; Abuhijla, Fawzi; Abu-Hijlih, Ramiz; Hussein, Tariq; Al-Gargaz, Wisam; Ghatasheh, Hamza; Hosni, Ali

doi:10.3390/jcm12082979

Cited by 5 publications

(1 citation statement)

References 23 publications

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“…On the other hand, the high toxicity of EBRT re-irradiation, including grade 3 and 4 events, is its main limitation, leading to a reduction of the total dose on CTV and therefore of its effectiveness, so that many centres never perform it and deem it too risky and/or not effective enough. In fact, available reports of patients submitted to re-irradiation with EBRT show toxicity rates ≥ G3 ranging from 18.3% to 50% 13 .…”

Section: Discussionmentioning

confidence: 99%

Interventional radiotherapy (brachytherapy) for re-irradiation of recurrent head and neck malignancies: oncologic outcomes and morbidity

Bussu,

Fionda,

Rigante

et al. 2024

Acta Otorhinolaryngol Ital

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SUMMARY Objective Management of recurrent head and neck cancer (HNC) is challenging. One option in previously irradiated patients is re-irradiation using interventional radiotherapy (IRT), the modern form of brachytherapy. Re-irradiation using IRT can be delivered as an exclusive strategy for salvage or through a postoperative or perioperative approach after salvage surgery. The aim of the present study is to analyse a bicentric Italian series focusing on the use of IRT as a re-irradiation modality and assess the resulting evidence concerning oncologic outcomes and morbidity. Methods This is a retrospective study performed in two referral centres in Italy: Policlinico Universitario Agostino Gemelli in Rome and Azienda Ospedaliera Universitaria in Sassari. All patients who had previously received a full course of external beam RT and have been re-irradiated using high-dose-rate IRT between December 2010 and June 2023 were included. Patients were retreated either by a combination of surgery and perioperative (either endocavitary or interstitial) IRT or by exclusive interstitial IRT. Results Thirty-four patients were included in the present series, 2 of whom underwent more than one IRT re-irradiation. Notably, no patient reported specific IRT-related toxicities. Median follow-up, excluding patients who died of HNC, was 24.5 months. Two-year local relapse-free survival was 26%, disease-specific survival 39.1%, and overall survival 36.6%. Conclusions The present series is the largest reported experience of re-irradiation by IRT for HNC in Italy. The very low rate of toxicity confirms IRT as the safest re-irradiation modality. It is noteworthy to underline that IRT is a multidisciplinary strategy based on the close cooperation between surgeons and radiation oncologists during every phase, from the recommendation of treatment and implantation in the operating theatre, to its prescription and dose painting.

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Section: Discussionmentioning

confidence: 99%

Interventional radiotherapy (brachytherapy) for re-irradiation of recurrent head and neck malignancies: oncologic outcomes and morbidity

Bussu,

Fionda,

Rigante

et al. 2024

Acta Otorhinolaryngol Ital

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Oral Health in Patients with History of Head and Neck Cancer: Complexity and Benefits of a Targeted Oral Healthcare Pathway

Florimond,

Duong,

Lours

et al. 2024

Curr Oncol Rep

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Purpose of Review This work consists in a literature review on the current state of knowledge regarding the oral management of patients with a history of head and neck cancer (HNC), corroborated by clinical cases and illustrated by clear infographic summaries. It aims to provide healthcare professionals with a comprehensive overview of the oral health status of HCN patients. Recent Findings Head and neck cancers (HNCs) represent the seventh most common type of cancer worldwide, with over 660,000 annual new cases. Despite the significant negative impact of HNCs on oral health, patients often receive no or inappropriate oral care while the significant impact of oral pathologies on cancer prognosis is commonly underestimated. Summary This work (i) describes the oral cavity during and after HNC through the prism of care complexity and (ii) highlights several potential key factors that could worsen long-time patients’ prognosis and quality of life. By investigating the biological, microbiological, functional, and psychological dimensions of the interrelationships between HNCs and oral health, the authors explored the barriers and benefits of a targeted oral healthcare pathway. This article emphasizes the importance of multidisciplinary care and highlights the need for further research elucidating the intricate relationships between oral health and HNCs, particularly through the microbiota.

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Reirradiation of squamous cell carcinoma of the head and neck with external photons: A practical review of the literature

Queyrel,

Lapierre,

Pointreau

et al. 2024

Cancer/Radiothérapie

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Re-Irradiation for Recurrent Head and Neck Cancer: Freedom from Cancer Recurrence Rate

Cited by 5 publications

References 23 publications

Interventional radiotherapy (brachytherapy) for re-irradiation of recurrent head and neck malignancies: oncologic outcomes and morbidity

Interventional radiotherapy (brachytherapy) for re-irradiation of recurrent head and neck malignancies: oncologic outcomes and morbidity

Oral Health in Patients with History of Head and Neck Cancer: Complexity and Benefits of a Targeted Oral Healthcare Pathway

Reirradiation of squamous cell carcinoma of the head and neck with external photons: A practical review of the literature

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