Re: Maternal transmission of SARS‐COV‐2 to the neonate, and possible routes for such transmission: a systematic review and critical analysis

Xue, Rui-Hong

doi:10.1111/1471-0528.16433

Cited by 2 publications

(2 citation statements)

References 4 publications

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“…25,26 Decreased levels of angiotensin-converting enzyme 2 in the nasopharyngeal epithelium and less-severe interleukin-6 responses during SAR-CoV-2 infection may be contributing to the clinical presentation. [25][26][27] Unlike the neonatal immune system, the immune system in adults shows increased response to "inflammation" and inflammatory stimuli called thymic involution. 6,28 We believe that the immature immune system of newborns play a role in the mild presentation of the disease observed in newborns.…”

Section: Discussionmentioning

confidence: 99%

Short-Term Outcomes in Neonates and Preterm Infants with SARS-CoV-2 Infection Acquired Postpartum

Karabay

Toptan

2021

J Pediatr Infect Dis

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Objective There are limited data regarding the hospital and postdischarge course of novel coronavirus disease 2019 (COVID-19) in newborns. This study aimed to present the data of such cases in newborns. Methods We retrospectively evaluated the predischarge and postdischarge records of newborns followed-up in the neonatal intensive care unit between June 2, 2020, and April 30, 2021 and who had positive polymerase chain reaction (PCR) test for COVID-19. Results Eleven newborns had positive PCR tests for COVID-19 during the study period. The prenatal COVID-19 PCR test of the mothers of the newborns was negative. The cases with a postnatal age of 10 to 60 days according to chronological age were hospitalized due to positive COVID-19 PCR test. Either or both the parents of these cases were severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) PCR positive on nasopharyngeal swab obtained simultaneously. All breast milk samples were negative for COVID-19 virus. The mean D-dimer value of the cases was 3,430 µg FEU/L at the time of hospitalization and 307 µg FEU/L after discharge. None of the cases were given any specific antiviral treatment. The cases were discharged with full recovery. No rehospitalizations or deaths occurred during the 3-month follow-up after discharge. Conclusion In most COVID-19 newborns, the disease was transmitted by infected parents, and the course of the infection was either asymptomatic or associated with only mild symptoms. No complications or deaths were observed during the 3-month follow-up after discharge.

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Section: Discussionmentioning

confidence: 99%

Short-Term Outcomes in Neonates and Preterm Infants with SARS-CoV-2 Infection Acquired Postpartum

Karabay

Toptan

2021

J Pediatr Infect Dis

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“…Thank you for the opportunity to comment on the letter by Dr Xue from Shanghai Jiao Tong University 1 . We agree there are many weaknesses in the data we reviewed 2 .…”

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confidence: 95%

Authors' reply re: Maternal transmission of SARS‐COV‐2 to the neonate, and possible routes for such transmission: a systematic review and critical analysis

Walker

O’Donoghue

Grace

et al. 2020

BJOG

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Re: Maternal transmission of SARS‐COV‐2 to the neonate, and possible routes for such transmission: a systematic review and critical analysis

Cited by 2 publications

References 4 publications

Short-Term Outcomes in Neonates and Preterm Infants with SARS-CoV-2 Infection Acquired Postpartum

Short-Term Outcomes in Neonates and Preterm Infants with SARS-CoV-2 Infection Acquired Postpartum

Authors' reply re: Maternal transmission of SARS‐COV‐2 to the neonate, and possible routes for such transmission: a systematic review and critical analysis

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