Carpal tunnel syndrome (CTS) is a condition in which there is median nerve entrapment within the carpal tunnel. The carpal tunnel is a small space in which nine tendons and the median nerve pass. Some authors consider it a closed space as it can behave as a closed compartment, and the median nerve may be affected by increased intracompartmental pressure. 1 Chronic CTS is the common form and can be treated conservatively or surgically. Conservative treatment is in the form of splinting, anti-inflammatory medication, and steroid injections (blind or ultrasound guided), while surgical is in the form of decompression (open or endoscopic). 2 On the other hand, acute CTS is rare. It is characterized by rapid progressive symptoms that arise in a matter of hours. It is mainly caused by fractures and/or dislocations around the wrist joint and less commonly caused by nontraumatic causes such as bleeding due to a bleeding disorder or from anticoagulant therapy. Acute CTS is a surgical emergency and requires urgent decompression to prevent undesired complications. 3 We present a case in which a patient suffered from iatrogenic acute CTS following a steroid injection to relief the symptoms of moderate CTS. The patient was a 43 year-old right-handed female dental nurse. She was complaining of tingling and numbness affecting the radial three digits for the last 12 months. Her symptoms progressed over the last 2 months, with increasing nocturnal pain, tingling, and numbness not responding to splints and anti-inflammatory medication. A nerve conduction study was organized and it showed mild-to-moderate CTS. The patient was injected 1 mL of 40-mg methylprednisolone þ 1 mL (0.25%) levobupivacaine into the carpal tunnel. The patient returned 24 hours later with worsening symptoms. She was referred to the accident & emergency department with worsening pain, numbness, and global hand weakness not responding to simple measures such as elevation and splintage. On examination, the patient was in severe pain at rest, paresthesia over the median nerve distribution, and weakness of the abductor pollicis brevis (Medical Research Council grade 3). Passive movement of the thumb, index, and middle fingers resulted in excruciating pain. There were no signs of infection at presentation. The clinical picture was consistent with acute CTS and urgent decompression was performed through an extended approach into the distal forearm. Intraoperatively, the median nerve sheath was swollen with chalky white powder deposits. There were no signs of nerve damage or infection. Serous fluid oozing from the nerve sheath was sent for Gram stain, culture, and sensitivity testing. No organisms were seen or grown from it. The patient had immediate relief of her median nerve symptoms postoperatively. The following day the patient was able to actively move the wrist, thumb, and fingers with minimal pain. The patient was followed up 2 weeks later. She had regained full muscle power strength and had normal sensation at that stage.Steroid injections are frequently us...