Re‐regeneration of lower jaws and the dental lamina in adult urodeles

Graver, Heber T.

doi:10.1002/jmor.1051570303

Cited by 16 publications

(15 citation statements)

References 15 publications

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“…Previous reports have shown that, despite their development as directly differentiating intramembranous bones, the jawbones of newts regenerate through a cartilage intermediate (Graver, 1978;Ghosh et al, 1994). We therefore tested whether a similar process occurs in zebrafish.…”

Section: Resultsmentioning

confidence: 99%

“…Although large bone lesions often fail to repair in mammals, many reptiles, amphibians and fishes can regenerate entire appendicular, tail and jaw skeletons (Goss and Stagg, 1958;Graver, 1978;Ghosh et al, 1994;Brockes, 1997;Iovine, 2007). A commonality between large-scale bone regeneration in these species and fracture healing in humans is the formation of a cartilage callus that bridges the wound, in particular when the fracture is not mechanically stabilized (Pritchard and Ruzicka, 1950;Lieberman and Friedlaender, 2005).…”

Section: Introductionmentioning

confidence: 99%

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Ihha induces hybrid cartilage-bone cells during zebrafish jawbone regeneration

et al. 2016

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The healing of bone often involves a cartilage intermediate, yet how such cartilage is induced and utilized during repair is not fully understood. By studying a model of large-scale bone regeneration in the lower jaw of adult zebrafish, we show that chondrocytes are crucial for generating thick bone during repair. During jawbone regeneration, we find that chondrocytes co-express genes associated with osteoblast differentiation and produce extensive mineralization, which is in marked contrast to the behavior of chondrocytes during facial skeletal development. We also identify the likely source of repair chondrocytes as a population of Runx2− cells that emanate from the periosteum, a tissue that normally contributes only osteoblasts during homeostasis. Analysis of Indian hedgehog homolog a (ihha) mutants shows that the ability of periosteal cells to generate cartilage in response to injury depends on a repair-specific role of Ihha in the induction as opposed to the proliferation of chondrocytes. The largescale regeneration of the zebrafish jawbone thus employs a cartilage differentiation program distinct from that seen during development, with the bone-forming potential of repair chondrocytes potentially due to their derivation from osteogenic cells in the periosteum.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ihha induces hybrid cartilage-bone cells during zebrafish jawbone regeneration

et al. 2016

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“…The complete amputation of the dental lamina of the vomer or of the palatine gives rise to toothless bones (Clemen, 1979 b ). Experiments dealing with repeated regeneration of the jaw have shown that the events, especially those involved in the repeated regeneration of the dental lamina, are the same as in normal regeneration but that the regrowth is more rapid (Graver, 1978).…”

Section: Tooth Regenerationmentioning

confidence: 99%

Amphibian teeth: current knowledge, unanswered questions, and some directions for future research

et al. 2007

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Elucidation of the mechanisms controlling early development and organogenesis is currently progressing in several model species and a new field of research, evolutionary developmental biology, which integrates developmental and comparative approaches, has emerged. Although the expression pattern of many genes during tooth development in mammals is known, data on other lineages are virtually non-existent. Comparison of tooth development, and particularly of gene expression (and function) during tooth morphogenesis and differentiation, in representative species of various vertebrate lineages is a prerequisite to understand what makes one tooth different from another. Amphibians appear to be good candidates for such research for several reasons: tooth structure is similar to that in mammals, teeth are renewed continuously during life (=polyphyodonty), some species are easy to breed in the laboratory, and a large amount of morphological data are already available on diverse aspects of tooth biology in various species. The aim of this review is to evaluate current knowledge on amphibian teeth, principally concerning tooth development and replacement (including resorption), and changes in morphology and structure during ontogeny and metamorphosis. Throughout this review we highlight important questions which remain to be answered and that could be addressed using comparative morphological studies and molecular techniques. We illustrate several aspects of amphibian tooth biology using data obtained for the caudate Pleurodeles waltl. This salamander has been used extensively in experimental embryology research during the past century and appears to be one of the most favourable amphibian species to use as a model in studies of tooth development.

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“…In amphibia, although regenerating teeth are said to be added in an alternating sequence in the lower jaws of adult Notophthalmus viridescens (Graver, 1978), the few investigations on early lower dentition development, e.g. in Hypogeophis rostr.…”

Section: Den Tit Ionmentioning

confidence: 99%

Development of the dentition in Alligator mississippiensis. Early embryonic development in the lower jaw

Westergaard

Ferguson

1986

Journal of Zoology

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Development of the dentition in a close series of accurately staged and aged embryos of Alligator mississippiensis was studied by macroscopy, light microscopy, scanning electron microscopy (SEM) and detailed reconstructions. Dental development in the lower jaw up to stage 18; day 26 is described in this paper. In the lower jaw, the first formed tooth germ appears at stage 14 in tooth family 3; the second at stage 15 in family 6; the third, fourth, fifth, sixth and seventh at stage 17 in families 12,2,4,9 and 16, respectively. Neither ‘Zahnreihen’ nor ‘perfect alternation’ theories of tooth initiation explain the data. Rather the present data suggest that initiation of teeth is related to jaw growth, the distance between existing teeth and the size and developmental maturity of the latter. Each tooth is postulated to have a ‘zone of inhibition’ around it. The first formed embryonic teeth are discernible by macroscopy and SEM as surface elevations (projecting tooth germs). The dental tissues of these are poorly differentiated and lack enamel. Projecting tooth germs sink into the jaw mesenchyme, their dental epithelia degenerate and they persist as non‐functional dentine rudiments for varying periods before becoming completely resorbed or shed. Formation of the dental lamina occurs by an overgrowth of the operculum (on which a distinct line of cobblestoned cells is visible by SEM) and closure of the dental furrow, as well as by the formation of a dental prolamina. The scaled fate maps and descriptive appearances of the developing alligator dentition highlight its value for future experimental studies of pattern formation and positional information.

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Re‐regeneration of lower jaws and the dental lamina in adult urodeles

Cited by 16 publications

References 15 publications

Ihha induces hybrid cartilage-bone cells during zebrafish jawbone regeneration

Ihha induces hybrid cartilage-bone cells during zebrafish jawbone regeneration

Amphibian teeth: current knowledge, unanswered questions, and some directions for future research

Development of the dentition in Alligator mississippiensis. Early embryonic development in the lower jaw

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