Re: SSRI use during pregnancy and risk for postpartum haemorrhage: a national register‐based cohort study in Sweden

Abstract

This registry-based large study of postpartum haemorrhage with SSRI usage, despite crucial limitations, shows any increased risk to be reassuringly low and clinically non-significant

Re: Pre‐eclampsia‐like syndrome induced by severe COVID‐19: a prospective observational study

“…Since all five of these subjects did not have evidence of preeclampsia before the diagnosis of severe COVID-19 pneumonia, we agree with Mendoza and colleagues' assessment of a similar underlying pathophysiology of pre-eclampsia and severe COVID-19. 1 One common denominator in the pathophysiology of pre-eclampsia and COVID-19 is endothelial injury. A hallmark of pre-eclampsia is disrupted placentation, which leads to endothelial dysfunction and end-organ damage.…”

“…Sir, We thank Dr Sholapurkar for showing interest in our register-based study on the risk of postpartum haemorrhage (PPH) in relation to depression and use of selective serotonin reuptake inhibitors (SSRIs) and for opening an important debate. 1 In his letter, Dr Sholapurkar raises possible limitations with register-based data. Specifically, that with large sample sizes, small effect sizes can be identified as statistically significant.…”

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Currie et al 1 that this topic is not fully explored and support the suggestion that lower urinary tract symptoms, urine microscopy and culture data should be included in future studies.

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Authors' reply re: SSRI use during pregnancy and risk for postpartum hemorrhage: a national register‐based cohort study in Sweden

“…We thank Dr Sholapurkar for showing interest in our register-based study on the risk of postpartum haemorrhage (PPH) in relation to depression and use of selective serotonin reuptake inhibitors (SSRIs) and for opening an important debate. 1 In his letter, Dr Sholapurkar raises possible limitations with register-based data. Specifically, that with large sample sizes, small effect sizes can be identified as statistically significant.…”

“…We thank Dr Sholapurkar for showing interest in our register‐based study on the risk of postpartum haemorrhage (PPH) in relation to depression and use of selective serotonin reuptake inhibitors (SSRIs) and for opening an important debate 1 …”