Re. SV40-like DNA sequences in pleural mesothelioma, bronchopulmonary carcinoma and non-malignant pulmonary disease

Ramael, Marc; Nagels, Jos

doi:10.1002/(sici)1096-9896(199912)189:4<628::aid-path481>3.0.co;2-5

Cited by 3 publications

(4 citation statements)

References 7 publications

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“…Conflicting results have been published on the association between different human tumors and SV40. Although this oncogenic PyV was previously associated with a broad range of tumor types including brain (213, 220, 234) and bone tumors (98), MPMs (80, 81, 227, 230), and different lymphoproliferative disorders (85, 239, 249, 254), other investigators reported negative results when analyzing the same tumor types (238, 275–279). In addition, these studies are mainly based on the detection of viral DNA.…”

Section: Discussionmentioning

confidence: 99%

“…The hypothesis that SV40 might be associated to human malignancies has been investigated with a large number of molecular, immunological, and epidemiological studies (Table 2). This oncogenic PyV was previously associated with a broad range of tumor types including, malignant pleural mesothelioma (MPM) (80, 81, 227–233, 235, 238, 240–243, 256–258), bone (98, 215, 224), brain (212–214, 217, 219–221, 259, 260), lung (227, 234), thyroid (82, 244), pituitary (179), and urothelial (245) tumors, pleomorphic adenomas of parotid glands (83), choroid plexus tumors, and ependymomas in children (160). In addition, footprints from SV40 DNA have been detected in breast (84) and colon cancer specimens (222).…”

Section: Association Of Sv40 With Human Tumorsmentioning

confidence: 99%

“…The association between SV40 and human tumors is based on results obtained by many investigators (80, 98, 213, 218, 220, 225, 227, 230, 234, 255, 256). Most of these studies detected SV40 DNA sequences, using qualitative PCR techniques, in tumor specimens.…”

Section: Association Of Sv40 With Human Tumorsmentioning

confidence: 99%

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Association Between Simian Virus 40 and Human Tumors

et al. 2019

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Simian virus 40 (SV40) is a small DNA tumor virus of monkey origin. This polyomavirus was administered to human populations mainly through contaminated polio vaccines, which were produced in naturally infected SV40 monkey cells. Previous molecular biology and recent immunological assays have indicated that SV40 is spreading in human populations, independently from earlier SV40-contaminated vaccines. SV40 DNA sequences have been detected at a higher prevalence in specific human cancer specimens, such as the brain and bone tumors, malignant pleural mesotheliomas, and lymphoproliferative disorders, compared to the corresponding normal tissues/specimens. However, other investigations, which reported negative data, did not confirm an association between SV40 and human tumors. To circumvent the controversies, which have arisen because of these molecular biology studies, immunological researches with newly developed indirect ELISA tests were carried out in serum samples from patients affected by the same kind of tumors as mentioned above. These innovative indirect ELISAs employ synthetic peptides as mimotopes/specific SV40 antigens. SV40 mimotopes do not cross-react with the homologous human polyomaviruses, BKPyV, and JCPyV. Immunological data obtained from indirect ELISAs, using SV40 mimotopes, employed to analyze serum samples from oncological patients, have indicated that these sera had a higher prevalence of antibodies against SV40 compared to healthy subjects. The main data on (i) the biology and genetics of SV40; (ii) the epidemiology of SV40 in the general population, (iii) the mechanisms of SV40 transformation; (iv) the putative role of SV40 in the onset/progression of specific human tumors, and (v) its association with other human diseases are reported in this review.

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Section: Discussionmentioning

confidence: 99%

Section: Association Of Sv40 With Human Tumorsmentioning

confidence: 99%

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Association Between Simian Virus 40 and Human Tumors

et al. 2019

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“…The oncogenic role of polyomavirus was formerly related with a wide array of tumor types for instance malignant pleural mesothelioma (MPM) and bone [11], brain [12], lung [13], thyroid [14], pituitary [15], and urothelial [16] tumors, pleomorphic adenomas of parotid glands [17], ependymomas choroid and plexus tumors in youth [18]. Additionally, footprints from DNA of SV40 have been reported in breast [19] and colon carcinoma [20].…”

Section: Introductionmentioning

confidence: 99%

The Dysregulation of Cyclin Dependent Kinase Regulators Role in SV40 Related Renal Cell Carcinoma

Kadhim

2024

SAJRM

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The purpose of this study was to explore the possible involvement of SV40 polyomavirus in the development of renal cell carcinoma (RCC) in patients from the province of Al-Najaf. The study analyzed 75 paraffin-embedded block tissues of RCC, collected from archives of AL-Sader Medical City, and some private histopathology laboratories in Najaf governorate. The patients included 45 males and 30 females, aged between 22 and 70 years. The study used advanced scientific techniques, including Polymerase Chain Reaction (PCR) and immunohistochemistry (IHC), to detect the presence of SV40 and evaluate the expression state of Cyclin-Dependent Kinase Regulators (KAP or cyclin-dependent kinase inhibitor 3 (CDKN3) & Cyclin E1 markers). Hematoxylin and Eosin staining was used for diagnosing RCC. The study found that RCC is associated with the dysregulation of Cyclin-Dependent Kinase regulators (CDK), caused by the SV40 polyomavirus. The results of the IHC analysis showed an increased positive percentage for KAP or CDKN3 marker and a decreased positive percentage of Cyclin E1 marker. Additionally, the clear cell type was found to be the most common, accounting for 56% of the cases, while grade I was the most prevalent, representing 41.3% of the cases. Tumor stage type I was found to be higher, with 25 cases. PCR detected the presence of SV40 in 20 cases, accounting for 26.7% of the total cases studied. The study concluded that the Simian Virus 40 (SV40), particularly its Large T Antigen (Tag), affects CDK regulators and disrupts the delicate equilibrium of cell cycle regulation systems. Therefore, the study suggests a possible link between the development of renal cell carcinoma and the SV40 polyomavirus. The study recommends routine testing for the detection of RCC using PCR and IHC methods.

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