Re: The Prostate Health Index Selectively Identifies Clinically Significant Prostate Cancer

Investigation on core-fucosylated prostate-specific antigen as a refined biomarker for differentiation of benign prostate hyperplasia and prostate cancer of different aggressiveness

“…The 4Kscore test measures a panel of four kallikreins (free PSA, total PSA, intact PSA, and kallikrein-like peptidase 2 (hK2)) Both tests are intended to reduce the number of unnecessary prostate biopsies in PSA-tested men and demonstrated to outperform PCa detection by %-free PSA. 27,28 These examples reveal that new markers in combination with conventional PSA are providing promise to aid in PCa diagnosis.…”

Early Detection of Prostate Cancer: AUA/SUO Guideline Part I: Prostate Cancer Screening. Letter.

“…This being said, we are afraid that these guidelines are leaving a quite open door to the risk of performing de novo prostatic biopsies, thus possibly leading to unacceptably high rates of grade group 1 (GG1) PCa diagnoses and subsequent overdiagnosis and overtreatment. 3,4 We concur on the importance of shared decisionmaking on PSA screening. However, we feel that the current version of the guidelines text might be interpreted by urologists as an endorsement to prescribe a prostatic biopsy in anyone who shows with 2 consecutive elevated PSA levels regardless of additional risk stratification tools.…”

“…Wang and colleagues measured the satisfaction of families after various pediatric urological procedures (pyeloplasty, ureteral reimplantation, and others) and different surgical approaches (open, laparoscopic, or robotic) and found no difference in survey results between them, which brings into question the actual relative importance of surgical access technique. 3 We commend Smith and colleagues for adding to the literature and presenting their outcomes with S-RALP; however, we think findings should be cautiously interpreted considering the issues highlighted. We agree that patient-centered investigations ought to define whether the single-port SP incision has value over open or M-RALP.…”

“…2 We have recently published a study in which we studied 526 patients with prostate cancer, 76% of which were Black patients, and found that 37% had an abnormal DRE. 3 Black patients comprise 15% of the US population and metropolitan areas have over 30% Black population. Therefore, we believe that DRE is a required component of prostate cancer screening, especially in high-risk patients, including Black patients and those with a family history of prostate cancer and/or genetic mutations associated with prostate cancer.…”

Prostate cancer characteristics in Black septuagenarian men

“…12 In 2020, we analysed an additional 310 patients who had a prostate biopsy in 2019 showing that the trend of increasing prostate cancer diagnosis continued. 13 In 2022, we 14 The current analysis examined the characteristics of men who completed a transrectal prostate biopsy in 2023. Data were collected on patient age, race, prostate-specific antigen (PSA), digital rectal examination (DRE), Gleason sum score (GSS) and grade group (GG).…”