Re-vaccination of 421 children with a past history of an adverse vaccine reaction in a special immunisation service

Gold, Michael; Goodwin, Helen; Botham, S J; Burgess, Margaret; Nash, Margot; Kempe, Ann

doi:10.1136/adc.83.2.128

Cited by 69 publications

(34 citation statements)

References 12 publications

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“…This information should be shared with parents and patients, since they are often worried that VAE might reappear after subsequent vaccination events. Indeed, this is the most common reason leading to revaccination refusal [9] and noncompletion of vaccination schedules [28].…”

Section: Discussionmentioning

confidence: 99%

Adverse Events Related to Vaccination (VAEs): How to Manage the Further Doses of Immunization and Parents’ Hesitancy

Gattinara¹,

Bellelli²,

Angelone³

et al. 2017

Vaccines

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This study supports the evidence that after vaccine-related reactions, it is still possible to carry out the immunization protocol.Out of more than 1000 patients per year evaluated for potential vaccine-related risks (patients with chronic/serious diseases and events connected with vaccination), 76 (6%) presented previous vaccine adverse events (VAEs). The decision about whether to continue child vaccination is made evaluating diferent factors: absence of speciic contraindications, parents' counseling, adequate hospital seting, choice of an appropriate and individualized schedule. None of the 76 children vaccinated after VAEs presented further side efects.Our data demonstrate that VAE is not a recurring event. The real risk of a new VAE is mostly associated with the serious allergic reactions (IgE-mediated anaphylaxis) and parents should be aware of this information, so that the widespread fear of VAE recurrence can be contained. Indeed, this type of concerns represents one of the main reasons for vaccination hesitancy, which leads to incomplete vaccination schedules.Conclusions: This chapter encourages clinicians to take advantage of the available VAE assessment algorithms to objectively evaluate real vaccine risk of VAE and provide parents with correct information, considering that VAEs are rare and severe reactions are extremely rare.

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Section: Discussionmentioning

confidence: 99%

Adverse Events Related to Vaccination (VAEs): How to Manage the Further Doses of Immunization and Parents’ Hesitancy

Gattinara¹,

Bellelli²,

Angelone³

et al. 2017

Vaccines

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“…Gold et al [20], after studying 970 children revaccinated with booster doses, concluded that only anaphylaxis and encephalopathy are absolute contraindications for continuing the vaccination programme. Katoulis et al [4] suggested that EM minor is a mild adverse reaction, and their studied patient completed the vaccination programme successfully.…”

Section: Discussionmentioning

confidence: 99%

The Quadrivalent Human Papillomavirus Vaccine: Erythema Multiforme and Cutaneous Side Effects after Administration

Pérez-Carmona¹,

Aguayo-Leiva²,

González-García³

et al. 2010

Dermatology

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The quadrivalent human papillomavirus (qHPV) vaccine, the first vaccine for use in the prevention of cervical cancer and condyloma acuminatum, was approved in June 2006. In 2008, the mass media reported suspected links between the qHPV vaccine and serious adverse events; however, several studies have found that the vaccine is safe and the main adverse events are mild local reactions. Erythema multiforme (EM) is an acute self-limited cutaneous or mucocutaneous syndrome characterized by the abrupt onset of symmetric target lesions. The clinical manifestations and histological features of EM, Stevens-Johnson syndrome and toxic epidermal necrolysis show considerable overlap, and they are classically considered to represent a spectrum of skin disorders. We present a case of EM following qHPV vaccination to review the cutaneous side effects of this vaccine and the possibility of more serious side effects with the administration of booster doses.

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“…In one study of 970 children revaccinated with booster doses, 469 experienced an adverse reaction, of whom 176 experienced a significant neurological or allergic reaction. The majority (421/469) of these children were revaccinated, and only 1 child developed a significant neurological event, which was transient and resolved spontaneously [16]. An adverse reaction following immunization, with the exception of anaphylaxis and encephalopathy, is no longer considered an absolute contraindication for continuing vaccination with the suspect vaccine [3].…”

Section: Discussionmentioning

confidence: 99%

Erythema Multiforme following Vaccination for Human Papillomavirus

et al. 2009

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Erythema multiforme (EM) is an acute self-limited immune-mediated reaction manifested by target skin lesions with mucous membrane involvement. The most common causes are infections and drugs. Vaccinations have been reported as a triggering factor, and they may be a frequent cause of EM in childhood. A 19-year-old female developed several target lesions of the hands and feet 10 days after the second dose of human papillomavirus (HPV) vaccine. Clinico-histologically, a diagnosis of EM minor was made. Treatment with topical corticosteroids and oral antihistamines resulted in complete clearance of the rash. Four months later, she received the last booster dose of the vaccine. A few subtle lesions appeared and disappeared spontaneously after a few days. Gardasil® is a non-infectious vaccine, developed for the prevention of cervical cancer, precancerous genital lesions and genital warts. It delivers the major capsid (L1) protein of HPV types 6, 11, 16 and 18. Mild local reactions are the main adverse events. The only serious events are very rare cases of anaphylaxis. In our patient, the temporal relationship between the development of EM and the vaccination suggests that the HPV vaccine probably was the causal agent. This is the first published case of EM following HPV vaccination.

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Re-vaccination of 421 children with a past history of an adverse vaccine reaction in a special immunisation service

Cited by 69 publications

References 12 publications

Adverse Events Related to Vaccination (VAEs): How to Manage the Further Doses of Immunization and Parents’ Hesitancy

Adverse Events Related to Vaccination (VAEs): How to Manage the Further Doses of Immunization and Parents’ Hesitancy

The Quadrivalent Human Papillomavirus Vaccine: Erythema Multiforme and Cutaneous Side Effects after Administration

Erythema Multiforme following Vaccination for Human Papillomavirus

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