Re(VII) and Tc(VII) trioxo complexes stabilized by tridentate ligands and their potential use as radiopharmaceuticals

Hahn, Eva M.; Casini, Angela; Kuehn, Fritz E.

doi:10.1016/j.ccr.2014.05.021

Cited by 21 publications

(14 citation statements)

References 87 publications

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“…[41] A similar trend was observed in amide-linked [42] (21 < 22 < 23 < 24) and oxamidato-linked [43] (25 < 26 < 27 < 28 < 29) compounds, suggesting that flexibility is important for modulating the biological activities of these complexes. Chalcogenolato-bridged compounds (30)(31)(32)(33)(34)(35)(36)(37) are generally less potent than the aforementioned complexes, with the exceptions of 31 and 33, which display significant cytotoxicity against Hep G2 cells. [44] Compound 24 is the most potent complex among these equatorially linked complexes, with cytotoxicity profiles similar to cisplatin.…”

Section: Linking Through the Para-positionmentioning

confidence: 99%

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Therapeutic and Diagnostic Applications of Multimetallic Rhenium(I) Tricarbonyl Complexes

Huang

Wilson

2021

Eur J Inorg Chem

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By virtue of their favorable properties, rhenium(I) tricarbonyl (Re(CO) 3 ) complexes have arisen as novel therapeutic agents and cellular imaging probes for addressing problems of biomedical relevance. Although great success has been found in monometallic complexes of this type, there has been recent interest in developing multimetallic compounds containing Re(CO) 3 moieties to capitalize on the potential synergistic effects of different metal centers. This Minireview provides an overview of multimetallic Re(CO) 3 complexes that have been developed specifically for biomedical applications. The promising therapeutic and diagnostic potential of such complexes and future needs in this field are discussed.

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Section: Linking Through the Para-positionmentioning

confidence: 99%

“…Readers are referred elsewhere for reviews on the biological applications of mononuclear Re(CO) 3 complexes, [1][2][3][4][5][6][7] multimetallic complexes in a more general sense, [29][30][31] and rhenium complexes where Re exists in oxidation states III, IV, V and VII. [6,33]…”

Section: Introductionmentioning

confidence: 99%

Therapeutic and Diagnostic Applications of Multimetallic Rhenium(I) Tricarbonyl Complexes

Huang

Wilson

2021

Eur J Inorg Chem

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“…Technetium chemistry, its cores and complexes, have been thoroughly reviewed in recent years [ 4 , 6 , 36 , 37 ]. The most frequently studied BFCA for Tc-complexes are summarized in Table 2 .…”

Section: Complexes and Radiolabeling Approaches For Target-specifimentioning

confidence: 99%

Advances in Development of Radiometal Labeled Amino Acid-Based Compounds for Cancer Imaging and Diagnostics

Mikulová

Mikuš

2021

Pharmaceuticals

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Radiolabeled biomolecules targeted at tumor-specific enzymes, receptors, and transporters in cancer cells represent an intensively investigated and promising class of molecular tools for the cancer diagnosis and therapy. High specificity of such biomolecules is a prerequisite for the treatment with a lower burden to normal cells and for the effective and targeted imaging and diagnosis. Undoubtedly, early detection is a key factor in efficient dealing with many severe tumor types. This review provides an overview and critical evaluation of novel approaches in the designing of target-specific probes labeled with metal radionuclides for the diagnosis of most common death-causing cancers, published mainly within the last three years. Advances are discussed such traditional peptide radiolabeling approaches, and click and nanoparticle chemistry. The progress of radiolabeled peptide based ligands as potential radiopharmaceuticals is illustrated via novel structure and application studies, showing how the molecular modifications reflect their binding selectivity to significant onco-receptors, toxicity, and, by that, practical utilization. The most impressive outputs in categories of newly developed structures, as well as imaging and diagnosis approaches, and the most intensively studied oncological diseases in this context, are emphasized in order to show future perspectives of radiometal labeled amino acid-based compounds in nuclear medicine.

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“…The Tc-trioxo core ([Tc(O 3 )] + ) embodies the technetium ion in its highest possible oxidation state (+7) [ 26 ] and it exhibits the C 3v scaffold that is particularly well suited for harboring a tripodal ligand. A general drawing of the structure of these scorpionate complexes is presented in Figure 4 [ 5 , 9 , 26 , 27 ]. Different synthetic pathways have been investigated for the synthesis of Tc-trioxo scorpionate complexes.…”

Section: Tc-trioxo Scorpionate Complexesmentioning

confidence: 99%

Technetium Complexes and Radiopharmaceuticals with Scorpionate Ligands

et al. 2018

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Scorpionate ligands have played a crucial role in the development of technetium chemistry and, recently, they have also fueled important advancements in the discovery of novel diagnostic imaging agents based on the γ-emitting radionuclide technetium-99m. The purpose of this short review is to provide an illustration of the most general and relevant results in this field, however without being concerned with the details of the analytical features of the various compounds. Thus, emphasis will be given to the description of the general features of technetium complexes with scorpionate ligands including coordination modes, structural properties and an elementary bonding description. Similarly, the most relevant examples of technetium-99m radiopharmaceuticals derived from scorpionate ligands and their potential interest for nuclear imaging will be summarized.

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Re(VII) and Tc(VII) trioxo complexes stabilized by tridentate ligands and their potential use as radiopharmaceuticals

Cited by 21 publications

References 87 publications

Therapeutic and Diagnostic Applications of Multimetallic Rhenium(I) Tricarbonyl Complexes

Therapeutic and Diagnostic Applications of Multimetallic Rhenium(I) Tricarbonyl Complexes

Advances in Development of Radiometal Labeled Amino Acid-Based Compounds for Cancer Imaging and Diagnostics

Technetium Complexes and Radiopharmaceuticals with Scorpionate Ligands

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