Re: What Are We Missing? False-negative Cancers at Multiparametric MR Imaging of the Prostate

Hajdinjak, Tine; Pelzer, Alexandre

doi:10.1016/j.eururo.2017.12.006

Cited by 4 publications

(8 citation statements)

References 3 publications

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“…As expected, the sensitivity increased with decreasing resolution of MRI datasets to larger voxel size (125.00 mm 3 ). Multiple prior studies evaluated the accuracy of prostate MRI at the ROI level, ranging from 6 ROIs to 30 ROIs, and on the voxel level . In a prior study by Priester et al, tumor extent was underestimated by more than 10 mm in 2/3 of cases, while in Le Nobin et al, underestimation was found to be somewhat smaller, suggesting a 9 mm safety margin in a study where the distance measurement was based on coregistration to histology.…”

Section: Discussionmentioning

confidence: 99%

“…A wide range of accuracy for PCa lesion detection and volume estimation has been reported . Multiple factors such as patient population, MRI acquisition and reporting protocols, and reference methods for standard coregistration of whole‐mount prostatectomy sections to in vivo MRI have major effects on the results.…”

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confidence: 99%

“…Multiple factors such as patient population, MRI acquisition and reporting protocols, and reference methods for standard coregistration of whole‐mount prostatectomy sections to in vivo MRI have major effects on the results. Multiple studies have also evaluated and improved coregistration of whole‐mount prostatectomy sections to in vivo MRI . However, external validation and implementation of methodology by other centers is limited by the lack of public access to datasets.…”

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confidence: 99%

“…A wide range of accuracy for PCa lesion detection and volume estimation has been reported. 5,[7][8][9][10][11][12][13][14] Multiple factors such as patient population, MRI acquisition and reporting protocols, and reference methods for standard coregistration of whole-mount prostatectomy sections to in vivo MRI have major effects on the results. Multiple studies have also evaluated and improved coregistration of whole-mount prostatectomy sections to in vivo MRI.…”

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confidence: 99%

“…Multiple studies have also evaluated and improved coregistration of whole-mount prostatectomy sections to in vivo MRI. 5,[7][8][9][10][11][12][13][14] However, external validation and implementation of methodology by other centers is limited by the lack of public access to datasets.…”

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confidence: 99%

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IMPROD biparametric MRI in men with a clinical suspicion of prostate cancer (IMPROD Trial): Sensitivity for prostate cancer detection in correlation with whole‐mount prostatectomy sections and implications for focal therapy

Merisaari

Jambor

Ettala

et al. 2019

Magnetic Resonance Imaging

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Background Prostate MRI is increasingly being used in men with a clinical suspicion of prostate cancer (PCa). However, development and validation of methods for focal therapy planning are still lagging. Purpose To evaluate the diagnostic accuracy on lesion, region‐of‐interest (ROI), and voxel level of IMPROD biparametric prostate MRI (bpMRI) for PCa detection in men with a clinical suspicion of PCa who subsequently underwent radical prostatectomy. Study Type Prospective single‐institution clinical trial (NCT01864135). Population Sixty‐four men who underwent radical prostatectomy after IMPROD bpMRI performed in prebiopsy settings. Field Strength/Sequence IMPROD bpMRI consisted of T2‐weighted imaging (T2w) and three separate diffusion‐weighted imaging acquisitions with an average acquisition time of 15 minutes. Assessment The diagnostic accuracy of prospectively reported manual cancer delineations and regions increased with 3D dilation were evaluated on the voxel level (volume of 1.17 mm3, 1 mm3, 125 mm3) as well as the 36 ROI level. Only PCa lesions with a diameter ≥ 5 mm or any Gleason Grade 4 were analyzed. All data and protocols are freely available at: http://petiv.utu.fi/improd Statistical Tests Sensitivity, specificity, accuracy. Results In total, 99 PCa lesions were identified. Forty (40%, 40/99) had a Gleason score (GS) of >3 + 4. Twenty‐eight PCa lesions (28%, 28/99) were missed by IMPROD bpMRI, three (7.5%, 3/40) with GS >3 + 4. 3D dilation of manual cancer delineations in all directions by ~10–12 mm (corresponding to the Hausdorff distance) was needed to achieve sensitivity approaching 100% on a voxel level. Data Conclusion IMPROD bpMRI had a high sensitivity on lesion level for PCa with GS >3 + 4. Increasing 3D lesion delineations by ~10–12 mm (corresponding to the Hausdorff distance) was needed to achieve high sensitivity on the voxel level. Such information may help in planning ablation therapies. Level of Evidence: 1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;50:1641–1650.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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confidence: 99%

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confidence: 99%

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IMPROD biparametric MRI in men with a clinical suspicion of prostate cancer (IMPROD Trial): Sensitivity for prostate cancer detection in correlation with whole‐mount prostatectomy sections and implications for focal therapy

Merisaari

Jambor

Ettala

et al. 2019

Magnetic Resonance Imaging

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Preliminary study on miRNA in prostate cancer

Abudoubari,

Bu,

Mei

et al. 2023

World J Surg Onc

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Objective To screen for miRNAs differentially expressed in prostate cancer and prostate hyperplasia tissues and to validate their association with prostate cancer. Methods Patients diagnosed by pathology in the Department of Urology of the First Affiliated Hospital of Xinjiang Medical University from October 2021 to June 2022 were selected, and their general clinical information, blood samples, and prostate tissue samples were collected. miRNA microarray technology was performed to obtain differentially expressed miRNAs in prostate cancer and hyperplasia tissues, and miRNAs to be studied were screened by microarray results and review of relevant literature. The detection of miRNA expression in the patients’ blood and prostate tissue samples was measured. The miRNA-222-mimics were transfected into PC3 cells, and cell biology experiments such as CCK8, scratch, Transwell, and flow cytometry were performed to detect the effects of overexpressed miRNA-222 on the growth and proliferation, invasive ability, apoptotic ability, and metastatic ability of prostate cancer cells. Results The results of the miRNA microarray showed that there were many differentially expressed miRNAs in prostate cancer and hyperplasia tissues, and four miRNAs, miRNA-144, miRNA-222, miRNA-1248, and miRNA-3651 were finally selected as the subjects by reviewing relevant literature. The results showed that the expression of miRNA-222 in prostate cancer tissues was lower than that in prostate hyperplasia tissues (P < 0.05). The expression of miRNA-222, miRNA-1248, and miRNA-3651 in blood samples of prostate cancer patients was lower than that in prostate hyperplasia patients (P < 0.05). The analysis results indicated that the f/t ratio and the relative expression of miRNA-222 and miRNA-1248 were independent influences of prostate cancer (P < 0.05), in which overexpression of miRNA-222 decreased the proliferative, invasive, and metastatic abilities of PC3 cells and enhanced the level of apoptosis of cancer cells. Conclusions Although there was no significant change in the overall incidence of prostate cancer in this study, significant changes occurred in the incidence of prostate cancer with different characteristics. In addition, the nomogram prediction model of prostate cancer-specific survival rate constructed based on four factors has a high reference value, which helps physicians to correctly assess the patient-specific survival rate and provides a reference basis for patient diagnosis and prognosis evaluation.

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Preoperative imaging accuracy in size determination of prostate cancer in men undergoing radical prostatectomy for clinically localised disease

Ageeli,

Soha,

Zhang

et al. 2023

Insights Imaging

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Objectives To compare the accuracy of pre-surgical prostate size measurements using mpMRI and USWE with imaging-based 3D-printed patient-specific whole-mount moulds facilitated histopathology, and to assess whether size assessment varies between clinically significant and non-significant cancerous lesions including their locations in different zones of the prostate. Methods The study population included 202 men with clinically localised prostate cancer opting for radical surgery derived from two prospective studies. Protocol-based imaging data was used for measurement of size of prostate cancer in clinically localised disease using MRI (N = 106; USWE (N = 96). Forty-eight men overlapped between two studies and formed the validation cohort. The primary outcome of this study was to assess the accuracy of pre-surgical prostate cancerous size measurements using mpMRI and USWE with imaging-based 3D-printed patient-specific whole-mount moulds facilitated histopathology as a reference standard. Independent-samples T-tests were used for the continuous variables and a nonparametric Mann–Whitney U test for independent samples was applied to examine the distribution and median differences between mpMRI and USWE groups. Results A significant number of men had underestimation of prostate cancer using both mpMRI (82.1%; 87/106) and USWE (64.6%; 62/96). On average, tumour size was underestimated by a median size of 7 mm in mpMRI, and 1 mm in USWE. There were 327 cancerous lesions (153 with mpMRI and 174 for USWE). mpMRI and USWE underestimated the majority of cancerous lesions (108/153; 70.6%) and (88/174; 50.6%), respectively. Validation cohort data confirmed these findings MRI had a nearly 20% higher underestimation rate than USWE (χ2 (1, N = 327) = 13.580, p = 0.001); especially in the mid and apical level of the gland. Clinically non-significant cancers were underestimated in significantly higher numbers in comparison to clinically significant cancers. Conclusions Size measurement of prostate cancers on preoperative imaging utilising maximum linear extent technique, underestimated the extent of cancer. Further research is needed to confirm our observations using different sequences, methods and approaches for cancer size measurement.

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Re: What Are We Missing? False-negative Cancers at Multiparametric MR Imaging of the Prostate

Cited by 4 publications

References 3 publications

IMPROD biparametric MRI in men with a clinical suspicion of prostate cancer (IMPROD Trial): Sensitivity for prostate cancer detection in correlation with whole‐mount prostatectomy sections and implications for focal therapy

IMPROD biparametric MRI in men with a clinical suspicion of prostate cancer (IMPROD Trial): Sensitivity for prostate cancer detection in correlation with whole‐mount prostatectomy sections and implications for focal therapy

Preliminary study on miRNA in prostate cancer

Preoperative imaging accuracy in size determination of prostate cancer in men undergoing radical prostatectomy for clinically localised disease

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