Reação anafilática ao corante azul patente durante a biópsia do linfonodo sentinela em câncer de mama inicial: relato de caso

Shinzato, Júlia Yoriko; Marcaccini, Ana Carolina Pereira; Braga, Angélica de Fátima de Assunção; Ribeiro, Arneth Rodrigues; Rubio, José Eduardo Marco; Souza, João Paulo

doi:10.1590/s0100-72032006001200007

Cited by 7 publications

(23 citation statements)

References 16 publications

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“…None of the animals used in this study exhibited immediate or late hypersensitivity reactions such as those described in the literature in humans (Del massa et al 2005, Shinzato et al 2006, Jeudy et al 2008, Bricou et al 2009, Hunting et al 2010, Lucas et al 2010, Rodrigues et al 2010, Hou-Chuan Lai et al 2011. According to the patient information leaflet, whatever is the route of administration, the Patent Bleu V ® solution (2.5%) is excreted within 24 to 48 hours in the bile and urine, the latter being more strongly colored.…”

Section: Discussionmentioning

confidence: 80%

Uterine lymphangiography: comparison of two methods for locating the medial iliac lymph node

et al. 2014

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ABSTRACT.-Justino R.C., Cardoso G.S., Trautwein L.G.C., Dessunti G.T., Oliveira D.V., Bernardes R. & Martins M.I.M. 2014. Uterine lymphangiography: comparison of two methods for locating the medial iliac lymph node. Pesquisa Veterinária Brasileira 34(11):1121-1126. Departamento de Clínicas Veterinárias, Universidade Estadual de Londrina, Rodovia Celso Garcia, Londrina, PR 86061-900, Brazil. E-mail: imartins@uel.br Different methods for lymphatic mapping in dogs, such as infusing tissues with vital dyes or radioactive substances, have been studied, aiming at the early detection of lymph node metastasis. Thus, one could anticipate therapeutic measures and, consequently, prolong the survival and improve the quality of life of the patients. The objectives of this experiment were to locate the nodes responsible for draining the uterine body and horns and to try to establish the relationship between the uterus and the medial iliac lymph nodes to contribute to the early diagnosis and prognosis of uterine disorders. We studied 15 female dogs divided into two groups (5 dead and 10 intraoperative ovariohysterectomy bitches). The dye used was patent blue V (Patent Bleu V ® ). It was observed that the iliac lymph node chain receives much of the uterine (horns) drainage. This method should be considered for safer studies of uterine sanity. This information suggests that evaluating these lymph nodes will allow correlating changes in their physiological status with uterine pathologies.INDEX TERMS: Sacral lymph node, aortic lymph node, vital dye, bitches.

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Section: Discussionmentioning

confidence: 80%

Uterine lymphangiography: comparison of two methods for locating the medial iliac lymph node

et al. 2014

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“…Many authors have described systemic cardiovascular signals associated with hypersensitivity in humans, and hypotension was the most cited (Shinzato et al 2006, Bricou et al 2009, Hunting et al 2010, Lucas et al 2010. Hypotension caused by an anaphylactic reaction to dyes can be confused with the hypotension commonly observed during anesthesia and is usually reversed by the pain stimuli from the surgical procedure, superficialization of anesthetic level, and an increase in intravenous fluids (Hunting et al 2010).…”

Section: Discussionmentioning

confidence: 99%

“…The use of blue dyes associated, or not, with local anesthetics can cause allergic reactions, suggesting that blue dye itself is a potential allergen (Hirsch et al 1982). There are no reports of adverse reactions in dogs using patent blue dye, but several reports of anaphylactic reactions are described in humans, with symptoms such as erythema, hypotension, tachycardia, and decreased oxygen saturation (Hirsch et al 1982, Del Massa et al 2005, Shinzato et al 2006, Jeudy et al 2008, Bricou et al 2009, Hunting et al 2010, Lucas et al 2010, Rodrigues et al 2010, Hou-Chuan Lai et al 2011.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of physiological parameters of dogs submitted to uterine lymphatic mapping using patent blue V dye for anaphylaxis detection

et al. 2016

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RESUMO.-[Avaliação de parâmetros fisiológicos de cães submetidos ao mapeamento linfático uterino usando o corante azul patente V para a detecção de anafilaxia.] O mapeamento linfático tem sido realizado em humanos e cães. Embora inúmeros casos de anafilaxia já tenham sido relatados em humanos, não existem tais relatos em cães. O objetivo deste estudo foi identificar a ocorrência de reações adversas ao corante azul patente V em cadelas submetidas ao mapeamento linfático uterino, usando avaliações cardiovasculares e hematológicas. O experimento foi realizado em 14 cadelas mestiças, divididas igualmente em dois grupos (PBV-mapeamento linfático uterino e OEH; Controle -apenas OEH). Os animais foram submetidos a exames hematológicos e bioquímicos séricos no pré e pós-operató-rio (7 dias). O protocolo anestésico foi: sedação (morfina e acepromazina), indução (propofol), manutenção (isoflurano), analgesia trans-operatória (fentanil Lymphatic mapping has been performed in humans and dogs. Although several cases of anaphylaxis have been reported in humans, there are no such reports in dogs. The objective of this study was to identify the occurrence of adverse reactions to patent blue V dye in bitches undergoing uterine lymphatic mapping procedures using cardiovascular and hematological evaluations. The experiment was performed in 14 mongrel bitches without any reproductive disease, randomly assigned into two equal groups (PBV-uterine lynphatic mapping and OHE; Control -OHE only). The animals were submitted to pre-and postoperative hematological and serum biochemistry exams (7 days). The anesthetic protocol was: sedation (morphine and acepromazine), induction (propofol), maintenance (isoflurane), transoperative analgesia (fentanyl). Systolic blood pressure was monitored throughout the procedure and arterial blood gas analysis was performed immediate pre and postoperatively. For lymphatic mapping was injected patent blue V in the uterine wall, 10 minutes before OEH. Comparisons between the pre-and postoperative parameters within the same animal were performed using the Wilcoxon-Mann-Whitney test. To compare the values between control and PBV group was obtaining the difference between the pre and post of each group, subjected to the Mann-Whitney test (significance of 5%). Differences were observed (P<0.05) between the pre-and postoperative evaluations in the PBV (total protein and the albumin serum), in both groups (arterial partial pressure of oxygen) and in the Control (arterial oxygen saturation). There were no signs of adverse reactions to the patent blue V dye in the healthy bitches submitted to lymphatic uterine mapping.INDEX TERMS: Uterine lymphatic mapping, patent blue V dye, anaphylaxis, hypersensitivity, bitches, vital dye.

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“…1,2 Para identificação do linfonodo pode ser usado o corante azul patente ou o radiofármaco tecnésio, ambos de forma isolada ou em associação. 1 No entanto têm sido relatadas reações de hipersensibilidade, mediada por IgE, ao corante azul patente, em uma incidência média de 1,8% (0,1% a 2,8%), reações essas em alguns casos severas, com repercussões hemodinâmicas graves, que necessitam de drogas vasoativas. [1][2][3][4] Essa frequência é superior à das reações de hipersensibilidade observadas durante a anestesia, que é em torno de 0,01% a 0,02%.…”

Section: Introductionunclassified

“…1 No entanto têm sido relatadas reações de hipersensibilidade, mediada por IgE, ao corante azul patente, em uma incidência média de 1,8% (0,1% a 2,8%), reações essas em alguns casos severas, com repercussões hemodinâmicas graves, que necessitam de drogas vasoativas. [1][2][3][4] Essa frequência é superior à das reações de hipersensibilidade observadas durante a anestesia, que é em torno de 0,01% a 0,02%. 5 Outro efeito observado com o uso do azul patente são as alterações da oximetria de pulso, em função da interferência na leitura do comprimento de onda, usado para medir a oxi-hemoglobina.…”

Section: Introductionunclassified

Reação alérgica ao corante azul patente em cirurgia de mama – relato de caso

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et al. 2016

Brazilian Journal of Anesthesiology

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We present a case of allergic reaction to patent blue in a patient who underwent excision of sentinel lymph node associated with segmental breast resection. About 20minutes after the dye injection, the patient developed hypotension (BP=70×30mmHg) associated with increased heart frequency. The patient was treated successfully with decreased inspired fraction of inhaled anesthetic and fluid replacement. At the end of the procedure, she presented with bluish urticarial - like plaques on the head, neck, upper limbs, and trunk; hydrocortisone was then used. The patient recovered uneventfully and was discharged from the PACU two hours after the end of surgery without skin changes, and was discharged from hospital on the morning after surgery. The incidence of allergic reactions with the use of patent blue is far superior to the hypersensitivity reactions seen with anesthetic and adjuvant drugs. Therefore, the anesthesiologist must be aware of cardiovascular instability associated with skin changes during the use of patent blue, for early diagnosis and appropriate treatment of this hypersensitivity reaction to this dye.

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Reação anafilática ao corante azul patente durante a biópsia do linfonodo sentinela em câncer de mama inicial: relato de caso

Cited by 7 publications

References 16 publications

Uterine lymphangiography: comparison of two methods for locating the medial iliac lymph node

Uterine lymphangiography: comparison of two methods for locating the medial iliac lymph node

Evaluation of physiological parameters of dogs submitted to uterine lymphatic mapping using patent blue V dye for anaphylaxis detection

Reação alérgica ao corante azul patente em cirurgia de mama – relato de caso

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