Reaction between 5-Benzylidene-2,2-Dimethyl-1,3-Dioxane-4,6-Dione and Tert-butyl Isocyanide in the Presence of Ethane-1,2-diol or Catechol

Sanaeishoar

Azad

et al. 2011

Self Cite

“…The 1 H-decoupled 13 C NMR spectrum of 4a showed 10 distinct resonances in agreement with the proposed structure. The 1 H-decoupled 31 P NMR spectrum of 4a * Correspondent.…”

supporting

confidence: 81%

“…IR spectra were measured on a Shimadzu IR-460 spectrometer. 1 H, 13 C, and 31 P NMR spectra were measured with a Bruker DRX-300 Avance spectrometer at 300.1, 75.5, and 121.5 MHz. Compounds 1-3 were obtained From Fluka and were used without further purification.…”

Section: Methodsmentioning

confidence: 99%

An Efficient One-Pot Synthesis of Trialkyl 2-(Dialkoxyphosphoryl)Ethene-1,1,2-Tricarboxylates

Sanaeishoar

Azad

et al. 2011

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“…Diethyl 2-[(cyclohexylimino) (3-methyl-4-oxo-5,5-diphenyl-2-thioxoimidazolidin-1-yl) Dimethyl 2-[(cyclohexylimino) (3-methyl-4-oxo-5,5-di-p-tolyl-2thioxoimidazolidin-1-yl) 6.28;N,7.48;S,5.71. Found: C,66.15;H,6.35;N,7. …”

Section: Scheme 2 Experimentalmentioning

confidence: 99%

A One-Pot Synthesis of Functionalised 1-Azadienes Containing 2-Thioxoimidazolidin-4-Ones

Ghanbari

Azizian

et al. 2011

Self Cite

“…IR: 1625, 1520, 1446 cm −1 . 1 H NMR (300 MHz, CDCl 3 ): 0.97 (3 H, t, 3 J = 6.1, Me), 1.36 (2 H, m, CH 2 ), 1.73 (2 H, m, CH 2 ), 2.02 (3 H, s, Me), 2.50 (3 H, s, Me), 3.84 (2 H, t, 3 J = 7.3, CH 2 N), 6.50 (1 H, s, CH), 7.30-7.37 (5 H, m, 5 CH) 13. C NMR (75 MHz, CDCl 3 ): 11.9 (Me), 14.9 (Me), 20.3 (CH 2 ), 31.4 (Me), 33.2 (CH 2 ), 46.7 (CH 2 N), 119.8 (CH), 21.9 (C), 125.9 (C), 126.9 (CH), 128.5 (2 CH), 129.7 (2 CH), 135.1 (C), 136.9 (C), 197.9 (C=O).…”

mentioning

confidence: 98%

Solvent-Free Synthesis of 1,2,3,4-Tetrasubstituted Pyrroles from Enaminones and β-Nitrostyrenes

Ghazvini

Aminkhani

2011

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A simple synthesis of 1,2,3,4-tetrasubstituted pyrrole derivatives from the reaction of enaminones with β-nitrostyrenes, under solvent-free conditions, is described.Pyrrole and its derivatives are an important class of heterocycles and many naturally occurring pyrroles exhibit bioactivity 1,2 and are used as anti-inflammatory, anti-tumor and immunosuppressive agents. 3,4 Moreover, some pyrroles have found applications in polymer technology. 5 A large number of methods have been developed for synthesis of pyrroles, which include Knorr, Paal-Knorr, and Hantzsch syntheses. 6-10 Enaminones are also employed in several new preparations of pyrrole derivatives. 11,12 As a part of our current studies on the development of new routes in heterocyclic synthesis, 12-16 we now report a convenient and catalyst-free synthesis of 1,2,3,4-tetrasubstituted pyrrole derivatives from the reaction of enaminones with β-nitrostyrenes, under solvent-free conditions (Scheme 1).The reaction of enaminones (1) and β-nitrostyrenes (2) proceeds at room temperature to produce tetrasubstituted pyrroles 3 in moderate to good yields (Scheme 1). The structures of compounds 3 were deduced from their IR, 1 H NMR, and 13 C NMR spectroscopic data. The mass spectra of these compounds displayed molecular ion peaks at appropriate m/z values. The 1 H NMR spectrum of 3a in CDCl 3 showed four singlets for methyl (δ = 2.04 and 2.45 ppm), methylene (δ = 5.08 ppm), and methine (δ = 6.56 ppm) protons, together with a multiplet (δ = 7.10-7.44 ppm) for the phenyl protons. The 13 C NMR spectrum of 3a showed 16 signals in agreement with the proposed structure. Partial assignments of these resonances are given in experimental section. * Correspondent.