Reaction between Isocyanides, Dialkyl Acetylenedicarboxylates and 2-Hydroxy-1-aryl-2-(arylamino)ethanones: One-Pot Synthesis of Highly Functionalized 2-Aminofurans

Abstract

A facile synthesis of highly functionalized 2-aminofuran derivatives by the multicomponent reaction of alkyl isocyanides, dialkyl acetylenedicarboxylates and 2-hydroxy-1-aryl-2-(arylamino)ethanone is described. The reaction is characterized by mild conditions, high selectivity, and tolerance to various functional groups.

Hal-Py-SO3H as a novel and recyclable catalyst for highly efficient synthesis of xanthene and spiropyran derivatives

“…Multicomponent reactions (MCRs) have become increasingly popular among chemists due to their ability to synthesize intricate molecules using easily accessible raw materials 17 . These reactions possess several advantages over sequential synthesis methods, including minimal waste production and the absence of unwanted by-products.…”

Synthesis of Highly Functionalised 1-Azadienes and Ketenimines by the Reaction of Alkyl Isocyanides and Dialkyl Acetylenedicarboxylates in the Presence of Theophylline Derivatives

“…10,11 The reaction of 1-azadienes with various chiral dienophiles, which leads to substituted pyridines, has been reported. 12,13 In the course of our work on the reaction between isocyanides and acetylenic esters, [14][15][16][17] we now report an efficient synthetic route to 1-azadienes and stable ketenimines using alkyl isocyanides 1, dialkyl acetylenedicarboxylates 2, and theophylline derivatives as strong NH-acids (Scheme 1).…”