2023
DOI: 10.21203/rs.3.rs-3198291/v1
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Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase

Leann Tilley,
Stanley Xie,
Yinuo Wang
et al.

Abstract: Malaria poses an enormous threat to human health. With ever increasing resistance to currently deployed drugs, breakthrough compounds with novel mechanisms of action are urgently needed. Here, we explore pyrimidine-based sulfonamides as a new low molecular weight inhibitor class with drug-like physical parameters and a synthetically accessible scaffold. We show that the exemplar, OSM-S-106, has potent activity against parasite cultures, low mammalian cell toxicity and low propensity for resistance development.… Show more

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