Reaction kinetics as a diagnostic tool for the gas chromatographic column

Reaction kinetic detection of void zones in gas chromatographic columns

“…Temperature was controlled to ±0.01 °C; gradients along the column were less than 0.1 °C. This ensured that irregularities in the product peak resulted from packing irregularities and not hot spots (5). In general, this degree of control is not required to apply the technique to ordinary columns.…”

“…Our study of several first order thermal decompositions in the gas-liquid chromatographic reactor {1-4) has shown that the shape of the reaction product curve on the chromatogram contains substantial information about the homogeneity of the column packing. Previously, reaction phenomena were used to investigate the condition of the solid support surface and to identify temperature gradients in the column (5). In view of the popularity of pre-packed analytical and preparative columns, we now expand this approach to column characterization to the detection of void spaces in the chromatographic column.…”

Gas chromatography

“…Solid Supports. Reaction kinetics involving the reaction of trioxane on TMS treated firebrick to form formaldehyde was shown (392) to be an effective means for studying the surface treatment of the solid support in GC. A Gas Chrom Q column showed no depolymerization of the trioxane.…”

The Gas Chromatographic Column as a Chemical Reactor

“…Unless the surface is the specific subject of interest, reactions should not be catalyzed by the support surface nor should the reactants injected into the reactor affect the surface treatments. Actually, we have used the catalytic characteristics of the support, for certain reactions, as a means of studying support treatment or deterioration of that treatment (58). The range of reactions amenable to study by the gas chromatographic method is further limited by the need for a relatively involatile solvent (liquid phase) and a vaporizable reactant.…”