Reaction Mechanisms in Organic Synthesis

Parashar, Rakesh Kumar

doi:10.1002/9781118681299

Cited by 6 publications

(3 citation statements)

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“…Norovirus (NoV) is a genetically diverse group of small, icosahedral, non-enveloped viruses with a positive-sense, single-stranded RNA (ssRNA) genome [110]. NoV demonstrates a significant level of contagion primarily attributed to its exceptionally low infective dose, with the estimated median infective dose (ID 50 ) ranging between 18 and 1015 genome copies [111].…”

Section: Nov-lpmentioning

confidence: 99%

Recent Advances in Nanozyme-Mediated Strategies for Pathogen Detection and Control

Ma,

Huang,

Cheng

2023

IJMS

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Pathogen detection and control have long presented formidable challenges in the domains of medicine and public health. This review paper underscores the potential of nanozymes as emerging bio-mimetic enzymes that hold promise in effectively tackling these challenges. The key features and advantages of nanozymes are introduced, encompassing their comparable catalytic activity to natural enzymes, enhanced stability and reliability, cost effectiveness, and straightforward preparation methods. Subsequently, the paper delves into the detailed utilization of nanozymes for pathogen detection. This includes their application as biosensors, facilitating rapid and sensitive identification of diverse pathogens, including bacteria, viruses, and plasmodium. Furthermore, the paper explores strategies employing nanozymes for pathogen control, such as the regulation of reactive oxygen species (ROS), HOBr/Cl regulation, and clearance of extracellular DNA to impede pathogen growth and transmission. The review underscores the vast potential of nanozymes in pathogen detection and control through numerous specific examples and case studies. The authors highlight the efficiency, rapidity, and specificity of pathogen detection achieved with nanozymes, employing various strategies. They also demonstrate the feasibility of nanozymes in hindering pathogen growth and transmission. These innovative approaches employing nanozymes are projected to provide novel options for early disease diagnoses, treatment, and prevention. Through a comprehensive discourse on the characteristics and advantages of nanozymes, as well as diverse application approaches, this paper serves as a crucial reference and guide for further research and development in nanozyme technology. The expectation is that such advancements will significantly contribute to enhancing disease control measures and improving public health outcomes.

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Section: Nov-lpmentioning

confidence: 99%

Recent Advances in Nanozyme-Mediated Strategies for Pathogen Detection and Control

Ma,

Huang,

Cheng

2023

IJMS

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“…In the past, quinine was a commonly used medication for the treatment of malaria, but nowadays it is rather prescribed and used for babesiosis, lupus, and arthritis. 60 From the point of view of applying the Rh 2 -method, in 3 and 4, the situation is more complicated at least for two reasons. 60 From the point of view of applying the Rh 2 -method, in 3 and 4, the situation is more complicated at least for two reasons.…”

Section: Quinine (3) and Quinidine (4)mentioning

confidence: 99%

“…56,57 Quinidine, a diastereoisomer of quinine, acts as a class I antiarrhythmic agent 58,59 and is present in the AD-mix-β mixture for Sharpless asymmetric dihydroxylation. 60 From the point of view of applying the Rh 2 -method, in 3 and 4, the situation is more complicated at least for two reasons. First, the presence of a tertiary quinuclidine nitrogen may hinder the formation of a chiral complex due to steric hindrance.…”

Section: Quinine (3) and Quinidine (4)mentioning

confidence: 99%

Chirality sensing of bioactive compounds with amino alcohol unit via circular dichroism

2017

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The aim of the present work was to test various chiroptical techniques, including in particular the in situ dirhodium methodology, to assign the absolute configuration of 1,2- and 1,3-amino alcohols. As models, we selected mainly compounds that have both an additional strongly absorbing and interfering chromophoric system and application in medicinal chemistry. Determination of the absolute configuration (AC) of the tested molecules such as cinchona alkaloids, Tamiflu, and others was carried out using a combination of electronic and vibrational circular dichroism (ECD, VCD) spectroscopy. It has been demonstrated that both 1,2- and 1,3-aminol moieties are subject to the same sector rule correlating stereostructure of formed Rh -complex with chiroptical properties, and that the changes in the position of the stereogenic center do not affect its proper use.

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Alkene Cross‐Metathesis Reactions

et al. 2021

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This chapter describes olefin cross‐metathesis (CM) reactions catalyzed by ruthenium, molybdenum, and tungsten complexes and surveys the literature from 1993 through 2020. Cross‐metathesis has been applied to the synthesis of a wide range of functionalized alkenes, including natural and biologically active products. Due to its simplicity and inherit atom economy, CM has found applications in the preparation of fine chemicals and various building blocks, and in transformations of biomass. Tandem reactions involving CM as the key step are also reviewed. Examples discussed in this chapter serve to illustrate how the reactivity of alkene substrates in CM depends on the presence of functional groups and steric congestion in the proximity of the reacting double bonds. A discussion of the mechanism of olefin metathesis is also included.

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Reaction Mechanisms in Organic Synthesis

Cited by 6 publications

References 0 publications

Recent Advances in Nanozyme-Mediated Strategies for Pathogen Detection and Control

Recent Advances in Nanozyme-Mediated Strategies for Pathogen Detection and Control

Chirality sensing of bioactive compounds with amino alcohol unit via circular dichroism

Alkene Cross‐Metathesis Reactions

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