Reaction of 2-methylbenzazoles with aromatic aldehydes in aqueous medium

Comparison of the Basic Strength of Solid Catalysts in the Synthesis of 2-Styrylbenzoxazoles under Microwave, Ultrasonic Irradiations and Solvent Free Conditions

“…The products were obtained in good yield and identified by comparison of their physical and spectroscopic data with those reported in literature [1][2] . The results are summarized in Table 1.…”

“…2-Styryl benzoxazoles are prepared via condensation of 2-methylbenzoxazole with aromatic aldehydes in presence of different catalysts and methods [1][2] . These compounds have diverse biological activities such as antiviral 3 , antisecretory 4 and different applications such as optical brightener 5 and dyes 6 .…”

Five‐Membered Heterocycles: 1,3‐Azoles

“…With suitable electrophilic reagents these anions undergo reasonably rapid and essentially non-reversible reaction. 2-Methyl and 2-ethylbenzothiazoles condense with aromatic aldehydes at room temperatures in 50% aqueous sodium hydroxide under phase-transfer catalysis conditions to afford secondary carbinols [453], while 2-methyl thiazole heated at 150 C with ZnCl 2 and benzaldehyde gives the styryl derivatives. To confirm the peculiar reactivity of the 2-alkyl group, neither 4-nor 5-methyl thiazole undergo such condensation.…”

Olefination of carbonyl compounds: modern and classical methods

“…Carbanions stabilised by an electron-deficient aromatic system can be used as olefinating agents. 2,6,181 Condensation of the corresponding CH-acids with aromatic aldehydes in the presence of bases is used for the preparation of non-symmetrical stilbenes or their heterocyclic analogues. 6 Pyridine, piperidine, alkali metal alkoxides and, less frequently, alkalis are commonly used as the bases.…”