Reaction of 4,5‐dichloro‐2‐chloromethylpyridazin‐3(2H)‐one with phenols

Abstract

in Wiley InterScience (www.interscience.wiley.com).The regiochemistry was investigated for the reaction of 2-chloromethyl-4,5-dichloropyridazin-3(2H)-one (1) with some phenols 2 in the presence of a base in organic solvents. Seven diphenoxy derivatives 5 were synthesized selectively from 1 and phenols 2 under two optimized conditions. The product distributions of these reactions are dependent on the base, the solvent, and/or the substitutes of phenols.