Reaction of alkyl isocyanides and dialkyl acetylenedicarboxylates in the presence of 5,5-diaryl thiohydantoins. Synthesis of functionalized imidazo[2,1-b][1,3]thiazines

One Pot Synthesis and Biological Activity Studies of New Spirooxindoles

“…Some derivatives of this compound have various critical biological properties, such as anti‐herpes virus, [23] anti‐cancer, [24,25] anti‐HSV, [26] anti‐HIV, [27,28] anti‐gene mutation, [29] anti‐malarial activity, [30] anti‐thyroid, [31] anti‐inflammatory, [32] anti‐bacterial and antioxidant [33] activities. Additionally, some of its derivatives are used as pesticides in agriculture [34] . Considering the numerous biological activities reported for spiroxindoles and thiohydantoins, we were encouraged to synthesize new spiroxindole derivatives including hydantoin moiety using 2‐thiohydantoin, isatin derivatives, and malononitrile and investigated their antibacterial and antioxidant activities (Scheme 1).…”

“…Additionally, some of its derivatives are used as pesticides in agriculture. [34] Considering the numerous biological activities reported for spiroxindoles and thiohydantoins, we were encouraged to synthesize new spiroxindole derivatives including hydantoin moiety using 2-thiohydantoin, isatin derivatives, and malononitrile and investigated their antibacterial and antioxidant activities (Scheme 1).…”