Reaction of Astaxanthin with Peroxynitrite

Hayakawa, Tsutomu; Kulkarni, Aditya; Terada, Yukimasa; Maoka, Takashi; Etoh, Hideo

doi:10.1271/bbb.80358

Cited by 22 publications

(20 citation statements)

References 8 publications

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“…However, this structure was misidentifi ed. The correct structure of 4 was reported in Hayakawa et al 12 as 13-apo-8-nitroastaxanthinone. In the present study, the structure of 4 was fully characterized by spectroscopic data Table 1 and 2 .…”

Section: Resultsmentioning

confidence: 70%

“…The identifi cation of 1, 5, and 9 was accomplished by the comparison of the physical and spectral data with those published in the literature 12 . The spectral data of 7 and 8…”

Section: Resultsmentioning

confidence: 99%

“…We previously reported that 4 is a reaction product of astaxanthin with peroxynitrite 12 . However, this structure was misidentifi ed.…”

Section: Resultsmentioning

confidence: 99%

“…However, little is known about the oxidation products of astaxanthin. We previously studied the reaction products of astaxanthin with peroxynitrite to reveal the oxidative degradation mechanism of astaxanthin with atmospheric oxygen and free radicals 11,12 . In the present study, we describe the isolation and identifi cation of reaction products formed during the self-initiated auto-oxidation of astaxanthin.…”

Section: Introductionmentioning

confidence: 99%

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Auto-Oxidation Products of Astaxanthin

et al. 2012

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Section: Resultsmentioning

confidence: 70%

“…The identifi cation of 1, 5, and 9 was accomplished by the comparison of the physical and spectral data with those published in the literature 12 . The spectral data of 7 and 8…”

Section: Resultsmentioning

confidence: 99%

“…We previously reported that 4 is a reaction product of astaxanthin with peroxynitrite 12 . However, this structure was misidentifi ed.…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Auto-Oxidation Products of Astaxanthin

et al. 2012

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“…Astaxanthin has been shown to be one of the most effective antioxidants against lipid peroxidation and oxidative stress in in-vitro and in-vivo systems (Barros et al, 2001). Its antioxidant activity is far higher than that of vitamin E (Hayakawa et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the in-vitro protective effect of plant extract (astaxanthin) on chromosomal breakage in Fanconi anemia cell culture

Eid¹,

Temtamy²,

Soliman³

et al. 2013

Middle East Journal of Medical Genetics

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BackgroundFanconi anemia (FA) is an inherited bone marrow failure syndrome associated with congenital abnormalities and hypersensitivity to DNA cross-linking agents. The high frequency of chromosomal breaks in FA lymphocytes has been related to the increased oxidative damage shown by these cells. Reactive oxygen species (ROS) are derived from the metabolism of molecular oxygen. It is now assumed that ROS are involved both in the initiation and in the progression of cancer. Antioxidants have the ability to transform ROS into stable and harmless compounds. Astaxanthin is a natural source of antioxidant; its effect might protect cells from oxidative damage. Its antioxidant activity is far higher than that of vitamin E. Aim of workThis study was designed to compare between the antioxidant effect of both astaxanthin and vitamin E as measured by their ability to reduce the frequency of induced chromosomal breakage in patients with FA. Participants and methodsThe current study included 15 patients with FA, nine females and six males, ranging in age from 4 to 21 years. The diagnosis of FA was confirmed by induction of chromosomal breakage by diepoxybutane. Astaxanthin and vitamin E were added at the start of the peripheral blood lymphocyte cultures to provide the possibility to improve the pro-oxidant state of the cells; then caffeine was added during the last 6 h of culture to induce chromosomal breakage. Results and conclusionThe level of breakage was markedly reduced using astaxanthin and vitamin E; however, there was no significant difference between the effects of both substances. Astaxanthin was found in a wide diversity of natural sources; also, it is 10 times more potent than vitamin A and much safer than vitamin E. Our study is the first to investigate the effect of astaxanthin on chromosomal breakage in vitro. We conclude that the administration could be beneficial for patients with FA to improve their hematopoietic state.

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Ergothioneine: a potential antioxidative and antimelanosis agent for food quality preservation

Kitsanayanyong

Ohshima

2022

FEBS Letters

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The global population increase has increased the demand for food products. However, post-harvest deterioration because of oxidation and discoloration results in a drastic loss of food quality and supply. Thus, research has focused on developing strategies to minimize such losses. One of those strategies includes the application of ergothioneine (ET), a potent hydrophilic antioxidant, to several food products to overcome their short shelf-life. ET can be synthetic or derived from several species of edible mushrooms and their extracts, which are known sources of natural ET. Given the reported potential of ET in food quality preservation, this review compiles the recent applications of ET as a preservative for maintaining the quality of food commodities.

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Reaction of Astaxanthin with Peroxynitrite

Cited by 22 publications

References 8 publications

Auto-Oxidation Products of Astaxanthin

Auto-Oxidation Products of Astaxanthin

Evaluation of the in-vitro protective effect of plant extract (astaxanthin) on chromosomal breakage in Fanconi anemia cell culture

Ergothioneine: a potential antioxidative and antimelanosis agent for food quality preservation

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