Reaction of geometrical isomers of retinoic acid with 1,2,4-triazoline-3,5-dione having fluorescent chromophore

Application of Cookson‐type reagents for biomedical HPLC and LC/MS analyses: a brief overview

“…After that report, DMEQTAD has been widely used for the detection and identification of marine toxins bearing conjugated dienes, such as yessotoxin, in a culture of the dinoflagellate by HPLC/FL and LC/MS/MS (Paz, Riobó, Fernández, Fraga, & Franco, ; Paz et al, ). DMEQTAD also reacted with retinoic acid isomers (vitamin A compounds), but gave a complicated mixture; its application to biological sample analysis has not been reported (Shimizu, Yaguchi, Iwasaki, & Yamada, ; Shimizu, Iwasaki, & Yamada, ).…”

“…(a) Derivatization reaction scheme of cis-9,trans-11-CLA (c9,t11-CLA) and trans-10,cis-12-CLA (t10,c12-CLA) with PTAD. (b) MS/MS fragmentation scheme of PTAD derivatives of CLAs isomers (vitamin A compounds), but gave a complicated mixture; its application to biological sample analysis has not been reported (Shimizu, Yaguchi, Iwasaki, & Yamada, 1994;Shimizu, Iwasaki, & Yamada, 1995).…”