Reaction of i-acetyl-2-phenyl-5-hydroxypyrazolidines with alcohols on the surface of adsorbents

Silica-Assisted Reactions of Pyrroles with 1-Acyl-2-bromoacetylenes

“…[1][2][3] Synthetic application of solid supports and chromatographic sorbents, including their modified forms, are steadily growing. [4][5][6] The use of silica as a solid support in the C-ethenylation of pyrroles with acylacetylenes proved to be advantageous; it allowed one to achieve significant reaction acceleration, improved regio-and stereoselectivity, and increased yields of adducts. 7,8 Acyl-haloacetylenes have not yet been studied in the reaction with pyrroles, although this would not only contribute to understanding the reactivity of both pyrroles and acylhaloacetylenes, but also provide a route to novel functionalized vinylpyrroles, potent building blocks for design of drugs 9 and advanced materials.…”