Reaction of methyl acrylate with N,N-dimethylethanolamine in the presence of a titanium alkoxide

TiCl4-promoted condensation of methyl acetoacetate, isobutyraldehyde, and indole: a theoretical and experimental study

“…Although the use of Ti(IV) in Michael-type reactions has been known for almost forty years 12 with important applications in organic synthesis, [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] the number of mechanistic studies on such reactions is limited. [18][19][20][21][22][23][32][33][34][35][36][37][38][39] This study might contribute to elucidation of the trimolecular Scheme 1 TiCl 4 -promoted trimolecular condensation.…”