Reaction of ozone with phosphatidylcholine liposomes and the lytic effect of products on red blood cells

Teige, Brita; McManus, T.T.; Mudd, J.B.

doi:10.1016/0009-3084(74)90071-1

Cited by 52 publications

(17 citation statements)

References 28 publications

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“…Additional reaction paths are available for CI's, including isomerization to the acid or reaction with water vapor, if present. 14,43,[46][47][48][49][50][51][52][53] The spectrum in Fig. 3 shows that even in the absence of added water vapor, adsorbed water is present on the surface of the OPPC/NaCl.…”

Section: This Journal Is C the Owner Societies 2008mentioning

confidence: 99%

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A new mechanism for ozonolysis of unsaturated organics on solids: phosphocholines on NaCl as a model for sea salt particles

Karagulian

Lea

Dilbeck

et al. 2008

Phys. Chem. Chem. Phys.

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PERSPECTIVEThe ozonolysis of an approximately one monolayer film of 1-oleoyl-2-palmitoyl-sn-glycero-3-phosphocholine (OPPC) on NaCl was followed in real time using diffuse reflection infrared Fourier transform spectrometry (DRIFTS) at 23 1C. Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry and Auger electron spectroscopy were used to confirm the identification of the products. Ozone concentrations ranged from 1.7 Â 10 12 to 7.0 Â 10 13 molecules cm À3 (70 ppb to 2.8 ppm). Upon exposure to O 3 , there was a loss of CQC accompanied by the formation of a strong band at B1110 cm À1 due to the formation of a stable secondary ozonide (1,2,4-trioxolane, SOZ). The yield of the SOZ was smaller when the reaction was carried out in the presence of water vapor at concentrations corresponding to relative humidities between 2 and 25%.

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Section: This Journal Is C the Owner Societies 2008mentioning

confidence: 99%

“…43, [46][47][48][49][50][51][52][53] However, the spectra in Fig. 4 also show that -CH 2 -groups are lost during the reaction.…”

Section: This Journal Is C the Owner Societies 2008mentioning

confidence: 99%

A new mechanism for ozonolysis of unsaturated organics on solids: phosphocholines on NaCl as a model for sea salt particles

Karagulian

Lea

Dilbeck

et al. 2008

Phys. Chem. Chem. Phys.

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“…Evidence of this reaction occurring in vivo was contained in the report that 0, degraded lung arachidonic acid (AA) in rodents exposed to 2.0 ppm 0, [Rabinowitz and Bassett, 19881. The by-products of the reaction of O1 with UFA in aqueous, cell free environments have been shown to be primarily carbonyl substances (aldehydesketones) and hydrogen peroxide (H202) [Pryor et al, 1991;Pryor, 1994;Santrock et al, 1992;Tiege et al, 1974;Madden et al, 19931. Increased concentrations of aldehydes were reported to be found in lung lavage fluid recovered from rats exposed to 1.3 ppm O3 for 10 hr [Cueto et al, 19921.…”

Section: Introductionmentioning

confidence: 99%

Products of ozonized arachidonic acid potentiate the formation of DNA single strand breaks in cultured human lung cells

Kozumbo

Hanley

Agarwal

et al. 1996

Environ. Mol. Mutagen.

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“…Tiege et al [19] proposed that in a hydrated environment (such as a hydrated lipid bilayer or airway lining fluid) the reaction of ozone with the carbon-carbon double bond of an unsaturated fatty acid would result in lysis of the double bond and formation of the corresponding aldehydes and hydrogen peroxide (ozonolysis). Santrock et al [17] confirmed this mechanism using a model membrane bilayer.…”

Section: Introductionmentioning

confidence: 99%

Rat lung phospholipid fatty acid composition in prepregnant, pregnant, and lactating rats: Relationship to ozone-induced pulmonary toxicity

Gunnison

Finkelstein

1997

Lung

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Our laboratory has demonstrated recently that pulmonary inflammation induced by acute ozone exposure is much more severe in late stage pregnant and lactating rats than in postlactating rats or age-matched virgin females. It is currently widely believed that such pulmonary damage results, at least in part, from the reaction of ozone at sites of unsaturation in phospholipid fatty acid (PLFA) molecules located in the epithelial fluid layer lining the lung surfaces and/or the plasma membranes of epithelial cells underlying this fluid layer. The objective of this study was to compare the PLFA composition of lung tissue and surfactant from ozone-sensitive late stage pregnant and lactating rats with comparable tissue from relatively ozone-insensitive age-matched prepregnant (virgin female) rats to explore the possibility that changes in lung PLFA composition during pregnancy and/or lactation contribute to the enhanced sensitivity of these physiologic states to ozone. In addition, the correlation of changes in plasma PLFA composition with those in lung was investigated. There were minor differences in the composition of lung tissue and surfactant PLFAs between prepregnant rats and pregnant rats at day 17 of gestation and only slightly greater differences between prepregnant and lactating rats. Changes from the prepregnant state in the PLFA composition of lung tissue, but not surfactant, correlated with changes in the plasma only in lactating rats and not in pregnant rats. Overall, the double bond index of PLFAs in surfactant and lung tissue was decreased in pregnant and lactating rats compared with prepregnant rats. Thus, the increased sensitivity of pregnant and lactating rats to ozone-induced lung injury cannot be attributed to an increased availability of unsaturated fatty acids. In addition, the arachidonic acid composition of phospholipids did not appear to explain differences between prepregnant rats and pregnant or lactating rats in their inflammatory response to ozone. In conclusion, there is no evidence that the relatively minor changes in lung tissue PLFA composition which occur during pregnancy and lactation predispose rats in these physiologic states to ozone-induced pulmonary toxicity.

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Reaction of ozone with phosphatidylcholine liposomes and the lytic effect of products on red blood cells

Cited by 52 publications

References 28 publications

A new mechanism for ozonolysis of unsaturated organics on solids: phosphocholines on NaCl as a model for sea salt particles

A new mechanism for ozonolysis of unsaturated organics on solids: phosphocholines on NaCl as a model for sea salt particles

Products of ozonized arachidonic acid potentiate the formation of DNA single strand breaks in cultured human lung cells

Rat lung phospholipid fatty acid composition in prepregnant, pregnant, and lactating rats: Relationship to ozone-induced pulmonary toxicity

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