Reaction of potassium dialkyl thiophosphates with ethynyl bromides in the presence of cupric chloride

Photoredox/copper-catalyzed coupling of terminal alkynes with P(O)SH compounds leading to alkynyl phosphorothioates

“…9 However, the construction of alkynyl phosphorothioates containing the C(sp)–S–P moiety is mainly accomplished by the nucleophilic reaction of P(O)SH with acetylene bromide which is not easy to store and odorous (Scheme 1d). 10 The success of photoredox formation of C(sp 3 )–S–P prompted us to investigate the green synthesis of alkynyl phosphorothioates. 11…”