Reaction of Tosylmethyl Isocyanide with N-Heteroaryl Formamidines: an Alternative Approach to the Synthesis of N-Heteroaryl Tosylimidazoles

Aryl Azides as Forgotten Electrophiles in the Van Leusen Reaction: A Multicomponent Transformation Affording 4-Tosyl-1-arylimidazoles

“…A literature search showed that 4-tosyl-1-arylimidazoles were already reported via different synthetic strategies. For example, they could be prepared by reacting arylazasulfones 5 with TosMIC or via oxidation of dilithiated 1-phenyl-4-tosyl-1 H -imidazole-5-thiol 6 with alkaline potassium ferricyanide or, finally, via reaction between aryl formamidate 7 or aryl formamidines and TosMIC in the presence of sodium hydride (Figure ).…”