Reaction of trithiazyl trichloride with active methylene compounds

Conformational and structural analysis of exocyclic olefins and ketimines by multinuclear magnetic resonance

“…The physical and spectroscopic properties of 1a, [10] 2a, [11] and 2b [12] are in good agreement with previous reports. These properties are listed in the Supplementary Material.…”

Synthesis of aromatic heterocycles

“…179 Activated methylene compounds similarly give disubstituted 1,2,5-thiadiazoles; thus, the thiadiazole 118 was isolated (41%) from a reaction with dibenzoylmethane. 180 More exotic structures are obtained from reactions of trithiazyl View Online chloride with pyrroles; an example is the bis(thiadiazole) 119 formed (45%) with 1-methyl-2,5-diphenylpyrrole. 181 1,2,5-Thiadiazoles have also been isolated in moderate yield from the reaction of tetrasulfur tetranitride or its antimony() chloride complex with oximes 182,183 and with isoxazoles.…”

Recent Developments in the Synthesis and Applications of 1,2,5-Thia- and Selenadiazoles. A Review

“…With trisubstituted ethene (Z)-ethyl 4-phenyl-3-benzylbut-2-enoate debenzylation takes place giving 4-phenyl-1,2,5-thiadiazole-3-carboxylate. 83 Also this method provided a new and efficient two-step route to 3-amino-1,2,5-thiadiazole starting from Nvinylphthalimide, 85 overcoming a problematic multi-step synthesis from aminoacetamidine and sulfur monochloride. 35…”

“…Treatment of ethenes with [(NSCl) 3 ] in benzene at reflux afforded 1,2,5-thiadiazoles 83 in moderate to good yields (Scheme 39). 83,85,86 The reaction may undergo the chlorination at allylic or benzylic positions, especially if excess of the trimer is used. With trisubstituted ethene (Z)-ethyl 4-phenyl-3-benzylbut-2-enoate debenzylation takes place giving 4-phenyl-1,2,5-thiadiazole-3-carboxylate.…”