Reactions in double emulsions by flow-controlled coalescence of encapsulated drops

Chen, Haosheng; Zhao, Yuanjin; Li, Jiang; Guo, Ming; Wan, Jiandi; Weitz, David A.; Stone, Howard A.

doi:10.1039/c1lc20265k

Cited by 84 publications

(50 citation statements)

References 22 publications

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“…Smectic freely suspended films (FSFs) can be prepared with well-defined thicknesses that are uniform on the scale of single molecular layers. [16] Oscillations of closed fluid interfaces driven by surface tension are of widespread interest in the contexts of, for example, technical, [17][18][19][20][21][22] chemical, [23,24] or biological [25][26][27] investigations. The investigation of these films has been focused mainly on director textures, electrical switching processes, optical characteristics and phase transitions, [4][5][6][7][8][9] where these films are a rich source of unique phenomena.…”

Section: Thin Fluid Filmsmentioning

confidence: 99%

“…This has recently been demonstrated in a microgravity study of smectic C bubbles. [16] Oscillations of closed fluid interfaces driven by surface tension are of widespread interest in the contexts of, for example, technical, [17][18][19][20][21][22] chemical, [23,24] or biological [25][26][27] investigations. For example, the dynamics of thin fluid films can essentially influence the stability of foams and emulsions.…”

Section: Thin Fluid Filmsmentioning

confidence: 99%

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Freely Floating Smectic Films

et al. 2014

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We have investigated the dynamics of freely floating smectic bubbles using high-speed optical imaging. Bubbles in the size range from a few hundred micrometers to several centimeters were prepared from collapsing catenoids. They represent ideal model systems for the study of thin-film fluid dynamics under well-controlled conditions. Owing to the internal smectic layer structure, the bubbles combine features of both soap films and vesicles in their unique shape dynamics. From a strongly elongated initial shape after pinch-off, they relax towards the spherical equilibrium, first by a slow redistribution of the smectic layers, and finally by weak, damped shape oscillations. In addition, we describe the rupture of freely floating smectic bubbles, and the formation and stability of smectic filaments.

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Section: Thin Fluid Filmsmentioning

confidence: 99%

Section: Thin Fluid Filmsmentioning

confidence: 99%

Freely Floating Smectic Films

et al. 2014

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“…Included in this section are recent advancements that make multicomponent microscale reactions possible through the coalescence of emulsion droplets in microfabricated devices. Stone and coworkers created double emulsions containing two inner drops that coalesce on demand, creating a protected environment where reagents do not interact until triggered . This emulsion droplet device was formed from three capillaries: one for injection, one for collection, and one to contain the flow of all phases.…”

Section: Droplet Generationmentioning

confidence: 99%

Microfabricated devices for biomolecule encapsulation

2012

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Biomolecule encapsulation in droplets is important for miniaturizing biological assays to reduce reagent consumption, cost and time of analysis, and can be most effectively achieved by using microfabricated devices. Microfabricated fluidic devices can generate emulsified drops of uniform size with controlled dimensions and contents. Biological and chemical components such as cells, microgels, beads, hydrogel precursors, polymer initiators, and other droplets can be encapsulated within these drops. Encapsulated emulsions are appealing for a variety of applications since drops can be used as tiny reaction vessels to perform high-throughput reactions at fast rates, consuming minimal sample and solvent amounts due to the small size (micron diameters) of the emulsion drops. Facile mixing and droplet coalescence allow for a diversity of assays to be performed on-chip with tunable parameters. The simplicity of operation and speed of analysis with microencapsulated drops lends itself well to an array of quantitative biomolecular studies such as directed evolution, single-molecule DNA amplification, single-cell encapsulation, high-throughput sequencing, enzyme kinetics, and microfluidic cell culture. This review highlights recent advances in the field of microfabricated encapsulating devices, emphasizing the development of emulsifying encapsulations, device design, and current assays that are performed using encapsulating droplets.

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“…Besides, the droplet formation process also needs a low temperature environment, otherwise the sol–gel reaction would happen at the room temperature, and the gels would block the microchannel. Even though the components of the sols have been improved and the low temperature environment is provided to elongate the working time, they cannot solve the gelation problem thoroughly since the gelation still happens in the premixed sols under these conditions. Therefore, it is urgent to develop a stable method to fabricate sol droplets for the internal gelation.…”

Section: Introductionmentioning

confidence: 99%

Droplet Micro‐Reactor for Internal Gelation to Fabricate ZrO₂ Ceramic Microspheres

et al. 2016

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A droplet micro‐reactor was developed to realize the internal sol–gel reaction of ZrO2 inside the droplet. The reactants are only allowed to combine when the droplet forms, meanwhile, they are able to mix well and react to form gel particles with a proper designed structure of the micro‐reactor. In this condition, the mixing efficiency was determined by the structure of the micro‐reactor and the flow rate ratio of the two components. After sintering, ZrO2 ceramic microspheres are acquired with high sphericity and narrow size distribution. This droplet micro‐reactor overcomes the gelation of the premixed sol and reactant in the channel, and it has been demonstrated to be more stable with a longer running time.

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Reactions in double emulsions by flow-controlled coalescence of encapsulated drops

Cited by 84 publications

References 22 publications

Freely Floating Smectic Films

Freely Floating Smectic Films

Microfabricated devices for biomolecule encapsulation

Droplet Micro‐Reactor for Internal Gelation to Fabricate ZrO₂ Ceramic Microspheres

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Reactions in double emulsions by flow-controlled coalescence of encapsulated drops

Cited by 84 publications

References 22 publications

Freely Floating Smectic Films

Freely Floating Smectic Films

Microfabricated devices for biomolecule encapsulation

Droplet Micro‐Reactor for Internal Gelation to Fabricate ZrO2 Ceramic Microspheres

Contact Info

Product

Resources

About

Droplet Micro‐Reactor for Internal Gelation to Fabricate ZrO₂ Ceramic Microspheres