Reactions of 26‐Iodopseudodiosgenin and 26‐Iodopseudodiosgenone with Various Nucleophiles and Pharmacological Activities of the Products.

Abstract

Steroids U 0300Reactions of 26-Iodopseudodiosgenin and 26-Iodopseudodiosgenone with Various Nucleophiles and Pharmacological Activities of the Products. -26-Iodopseudodiosgenin (I) and 26-iodopseudodiosgenone (IV) are treted with a variety of nucleophiles. Compounds such as (III), (V), (VI), (VIII), (IX), (XI), and (XII) show strong cytotoxic activities against HCT 116 cells. Products such as (VII), (XIb), (XIc), and (XII) exhibit strong effects against Hep G2 cells. -(QUAN, H.-J.; KOYANAGI, J.; HAGIWARA, K.; CUI, X.-R.; ISSHIKI, Y.; KONDO, S.; KOMADA, F.; SAITO*, S.; Chem. Pharm. Bull. 54 (2006) 1, 72-79; Fac. Pharm. Sci., Josai Univ., Sakado, Saitama 350-02, Japan; Eng.) -M. Bohle 31-172