Reactions of 4-(2-aminothiazole-4-yl)-3-methyl-5-oxo-1-phenyl-2-pyrazoline. Synthesis of thiazolo[3,2-a]pyrimidine and imidazo[2,1-b]thiazole derivatives

A rapid access to novel and diverse 3-oxothiazolo[3,2- $$c$$ c ]pyrimidine-8-carboxylates using multicomponent Mannich cyclisation reactions

“…Also, thiazolo[3,2-a]pyrimidines can be considered as another important derivative of thiazolopyrimidines. Both types exhibit a variety of biological properties, such as antitumor and cytotoxic [3], immunomodulatory [4], antimicrobial [5,6], antipsychotic [7], antiinflammatory [8,9,17], calcium antagonist [10], antiviral [11], antiparkinsonian [12], antiarrhythmic [13], antidepressant [14], anticancer [15,18], and analgesic [16] activities ( Fig. 1).…”

Synthesis and Growth Stimulant Properties of 2-Acetyl-3,7-dimethyl-5H-thiazolo[3,2-a]pyrimidin-5-one Derivatives

“…Due to the great potential of both of the moiety, different scientists synthesized a large number of thiazolopyrimidines derivatives in particular thiazolo [3,2-a]pyrimidines with different substituents to evaluate their various pharmacological activities. The survey of literature reveals that these fused biheterocyclic compounds show pharmacological properties like anti-inflammatory [1][2][3], bactericidal [4][5][6][7][8][9], analgesic and antiparkinsonian [10], antifungal [6,7,9,[11][12][13][14], antioxidant [6,9,15], anticancer [16][17][18][19][20], antimicrobial [9,[21][22][23][24][25][26], hypoglycemic [27], psychopharmacological [28], antituberculosis [29], antidepressant [30], and antiviral [31,32]. Some derivatives are offered as acetylcholinesterase inhibitors [3], antipsychotic agents [33], calcium antagonists [34], phosphate inhibitors [35,36], and 5-HT2A receptor antagonists…”

“…aminothiazoles are used. In most of the papers the synthesis of initial pyrimidine-2-thione derivatives is carried out via Biginelli multicomponent condensation reaction of substituted aldehydes with 1,3-dicarbonyl compounds and thiourea [3,6,8,9,13,20,23]. In some cases, pyrimidines were obtained in two steps [20].…”

Synthesis of some new derivatives of thiazolopyrimidines and hydrolysis of its arylidene derivative

“…These have generated interest in recent years due to their biological and pharmaceutical activities. These ring systems have shown anti-microbial, [1][2][3][4] anti-malarial, 5 anti-inflammatory, 6,7 anti-oxidant, 6 anti-nociceptive 7 and antitubercular 8 activity. In addition, they have been reported to possess anti-tumour activity 9,10 and have also shown to possess anti-parkinsonian and anti-proliferative properties.…”