Reactions of Amidoximes with Metal-Activated Nitriles

Bolotin, Dmitrii S.

doi:10.1134/s1070328418040024

Cited by 3 publications

(2 citation statements)

References 42 publications

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“…[12,13,14] In this method, the metal ion's reactivity is used to activate and alter a pro-ligand in situ, resulting in coordination compounds with ligands that are generally not accessible via standard organic synthesis. [15,16,17,18,19,20] In this regard, coordination chemists have used nitrile-based ligands to prepare metal complexes, in which they observed the in situ conversion of nitriles into imines, amides, carboxylic acids, and heterocyclic ligands. [21,22,23,24,25] When nitriles are coordinated with metal cations, they become highly susceptible to nucleophilic attack.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Six New Transition Metal Complexes: Structural Characterization and in vitro α‐Glucosidase Inhibitions Studies

et al. 2023

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Three one‐pot reactions leading to six new transition metal complexes are presented. The one‐pot reactions involved transformations of 2‐(N’‐dicyanomethylene‐hydrazino)‐benzoic acid (DHB) into three new ligands (Lig‐I)2−, (Lig‐II)2−, and (Lig‐III)2−. The complex [Ni2(Lig‐I)2] ⋅ 3H2O (1) was prepared in a one‐pot synthesis in which ligand, (Lig‐I)2− was formed by the amination of DHB resulting from the nucleophilic attack of an amino group of ethylenediamine (en). The complex [Cu(Lig‐II)(en)(H2O)] (2) was prepared in a one‐pot synthesis in which ligand, (Lig‐II)2− was formed by the nucleophilic attack of an amino group of en resulting in an imidazole ring formation. The dinunclear complexes [Zn2(Lig‐III)2(CH3OH)2] (3) and [Cu2(Lig‐III)2(CH3OH)2] (4), a linear trinuclear complex [Ni3(Lig‐III)(en)2(CH3OH)] (5), and a mononuclear complex [Mn(Lig‐III)(CH3OH)4] (6) were synthesized using a preparation involving conversion of one of the nitriles on DHB into an imino‐ester. The resulting complexes were characterized using a variety of analytical techniques including infra‐red and UV‐vis spectroscopy, elemental analysis, and single‐crystal X‐ray diffraction analysis. The complexes displayed α‐glucosidase enzyme inhibition with IC50 values in the range of 1.57–207 μM.

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Section: Introductionmentioning

confidence: 99%

Synthesis of Six New Transition Metal Complexes: Structural Characterization and in vitro α‐Glucosidase Inhibitions Studies

et al. 2023

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“…Numerous research papers have been published in this field. Specifically we would like to highlight the reactivity of coordinated nitriles in the Pt coordination sphere [33][34][35][36][37] or reactivity of triosmium clusters toward a wide range of substrates [38][39][40][41]. UVirradiation (or photolysis) is a well-known technique for a lot of chemical processes, including (i) ligand exchange reactions (e.g., low-valence iron, osmium clusters) [42,43], (ii) ligand transformation [44][45][46], and (iii) CO2 capture [47].…”

Section: Introductionmentioning

confidence: 99%

Easy Ligand Activation in the Coordination Sphere of Ru inside the [PW11O39]7– Backbone

et al. 2020

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Irradiation of the Keggin-type [PW11O39{Ru(NO)}]4− (Ru-NO) polyoxometalate in CH3CN results in rapid NO ligand elimination with the formation of [PW11O39{RuIII(CH3CN)}]4− (Ru-CH3CN). This complex offers an easy entry into the Ru-based chemistry of the {PW11Ru} complex. Attempts to substitute N3− for CH3CN in the presence of an NaN3 excess lead a variety of products: (i) [PW11O39{RuIII(N3)}]4− (Ru-N3); (ii) [PW11O39{RuIII(N4HC-CH3)}]4− (Ru-Tz) as a click-reaction product; and (iii) [PW11O39{RuII(N2)}]5− (Ru-N2). UV-VIS, CV, and HR-ESI-MS techniques were used for the reaction monitoring and characterization of the products.

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A DFT mechanistic study of the synthesis of trans-Z,Z-[PtIICl(NH3){HN = C(NH2)Me}2]Cl from addition of NH3 to trans-[PtIICl2(N CMe)2]

Casella

Carlotto

Mozzon

et al. 2020

Inorganica Chimica Acta

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Reactions of Amidoximes with Metal-Activated Nitriles

Cited by 3 publications

References 42 publications

Synthesis of Six New Transition Metal Complexes: Structural Characterization and in vitro α‐Glucosidase Inhibitions Studies

Synthesis of Six New Transition Metal Complexes: Structural Characterization and in vitro α‐Glucosidase Inhibitions Studies

Easy Ligand Activation in the Coordination Sphere of Ru inside the [PW11O39]7– Backbone

A DFT mechanistic study of the synthesis of trans-Z,Z-[PtIICl(NH3){HN = C(NH2)Me}2]Cl from addition of NH3 to trans-[PtIICl2(N CMe)2]

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