Reactions of carboline

Dardonville, Christophe; Virelizier, H.; Boivin, Jean; Jankowski, Christopher K.

doi:10.1155/1997/821241

Cited by 2 publications

(3 citation statements)

References 16 publications

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“…Under strict temperature and time control as applied in the here-described experiments, an intramolecular shift of the oxygen is very unlikely. Furthermore, the proposed structure of 3 was also supported by the radiolysis of 2-thiopyridine derivatives (23). Sulfoxides instead of N-oxides were observed as reaction products.…”

Section: Isolation and Structure Elucidation Of The Precursormentioning

confidence: 71%

“…1 H NMR (500. 16 MHz, acetonitrile-d 3 ): δ 1.14 (s, 9, H22, H22, H22, H23, H23, H23, H24, H24, H24), 3.56 (dd, 1, J = 14.03, 10.02 Hz, H8), 3.89 (dd, 1, J = 14.03, 4.58 Hz, H8), 5.84 (dd, 1, J = 10.02, 4.58 Hz, H9), 6.88 (dt, 1, J = 0.86, 8.31 Hz, H15), 6 (10), 61 (23), 63 (26), 78 (9), 93 (100), 109 (11), 111 (11), 112 (12), 126 (4), 142 (3) 174 (5), 220 (5). Sodium adduct C 7 H 9 NOS 3 Na: HR-ESI-MS, 241.9749; MS calculated, 241.9744.…”

Section: Hplc Separation Of Thementioning

confidence: 99%

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Isolation and Identification of a New Cysteine Sulfoxide and Volatile Sulfur Compounds from Allium Subgenus Melanocrommyum

Kusterer

Vogt

Keusgen

2009

J. Agric. Food Chem.

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A new cysteine sulfoxide containing a pyridyl residue was identified in bulbs of Allium L. species belonging to the subgenus Melanocrommyum section Megaloprason. One of these species, Allium stipitatum, is widely used as a crop plant and in folk medicine in Central Asia. The new cysteine sulfoxide was identified as L-(+)-S-(2-pyridyl)-cysteine sulfoxide. Aside from this cysteine sulfoxide, several pyridyl compounds could be identified, which were formed out of cysteine sulfoxides by the action of alliinase. Found cysteine sulfoxides and their metabolites are chemically unstable; thus, the analysis is rather difficult. By combining high-performance liquid chromatography (HPLC), HPLC tandem mass spectrometry, NMR, IR, and photometric methods, full structure elucidation of the cysteine sulfoxide was possible. Alliinase reaction products were mainly determined by various MS techniques. The achieved results give new insights in the chemistry of Allium crop plants and are probably useful for chemotaxonomical classification of the subgenus Melanocrommyum.

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Section: Isolation and Structure Elucidation Of The Precursormentioning

confidence: 71%

Section: Hplc Separation Of Thementioning

confidence: 99%

Isolation and Identification of a New Cysteine Sulfoxide and Volatile Sulfur Compounds from Allium Subgenus Melanocrommyum

Kusterer

Vogt

Keusgen

2009

J. Agric. Food Chem.

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“…Hence in search for new HAT chemotherapy Dardonville C et al [57] decided to carry out an in vitro screening of a total of 62 compounds against the parasite T. brucei rhodesiense taken from their in-house library. Based on this they showed that bisguanidine and especially bis(2-aminoimidazoline)diphenyl compounds displayed potent anti-trypanosomal activity in vitro and vivo against T. b. rhodesiense, the causative agent of acute HAT [58,59]. Among the 62 compounds screened, compounds1c, 28b, 32b and 41b ( Figure 17) showed excellent in vitro activity (49nM, 69 nM, 22 nM and 118 nM respectively) as well as high selectivity (>5294, 3072, 29.5 and 881respectively) for the parasite.…”

Section: Bis(2-aminoimidazoline) and Bisguanidinementioning

confidence: 99%

Neglected Disease – African Sleeping Sickness: Recent Synthetic and Modeling Advances

Paliwal

Verma²,

Paliwal³

2011

Sci. Pharm.

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Human African Trypanosomiasis (HAT) also called sleeping sickness is caused by subspecies of the parasitic hemoflagellate Trypanosoma brucei that mostly occurs in sub-Saharan Africa. The current chemotherapy of the human trypanosomiases relies on only six drugs, five of which have been developed more than 30 years ago, have undesirable toxic side effects and most of them show drug-resistance. Though development of new anti-trypanosomal drugs seems to be a priority area research in this area has lagged far behind. The given review mainly focus upon the recent synthetic and computer based approaches made by various research groups for the development of newer anti-trypanosomal analogues which may have improved efficacy and oral bioavailability than the present ones. The given paper also attempts to investigate the relationship between the various physiochemical parameters and anti-trypanosomal activity that may be helpful in development of potent anti-trypanosomal agents against sleeping sickness.

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Reactions of carboline

Abstract: The reactions of carboline under various oxidative conditions are reported. The soft aerobic radiolysis, hydroxylation and rearrangement transformations are studied using isotopic labelling and GC–MS techniques.

Cited by 2 publications

References 16 publications

Isolation and Identification of a New Cysteine Sulfoxide and Volatile Sulfur Compounds from Allium Subgenus Melanocrommyum

Isolation and Identification of a New Cysteine Sulfoxide and Volatile Sulfur Compounds from Allium Subgenus Melanocrommyum

Neglected Disease – African Sleeping Sickness: Recent Synthetic and Modeling Advances

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