Reactions of diorganotin(IV) oxides with isatin 3- and 2-thiosemicarbazones and with isatin 2,3-bis(thiosemicarbazone): influence of diphenyldithiophosphinic acid (isatin = 1H-indole-2,3-dione)

Synthesis, characterization and in vitro cytotoxicity of homobimetallic complexes of palladium(II) with 2‐thiouracil ligands. Crystal structure of [Pd2(TU)(PPh3)3Cl2]

“…The complexation of two Pd atoms with one ligand through both N atoms is confirmed by the absence Bioorganometallic Chemistry of the (N6-)H6 and (N2-)H2 signals that were present in the spectrum of 2-thiouracil, whereas the (N2-)H2 singlet appears at 12.54 ppm in the one Pd atom complexes 3-5. The (C4-)H4 and (C5-)H5 protons resonances are shifted downfield at 5.97 ppm (unresolved doublet) and 5.86 ppm (well resolved doublet) as compared with the free 2-thiouracil ( δ = 0.026, 3 J H,H = 7.8 Hz), respectively, in the complexes 1-5, 32 implying a lowering of the bond order as a consequence of the thione → thiol tautomerization during complexation. 33 During complexation, 2-thiouracil behaves as bidentate via S/N in one-Pd complexes 3-5 and as a bridging moiety coordinated to palladium via N and S/N atoms in complexes 1 and 2.…”

Synthesis, characterization and biocidal activity of some transition metal(II) complexes with isatin salicylaldehyde acyldihydrazones

“…Electronic spectra of the complexes were recorded on a Shimadzu spectrophotometer, model, Pharmaspec UV-1700 in nujol. Magnetic susceptibility measurements were performed at room temperature on a Faraday balance using Hg[Co(SCN) 4 ] as the calibrant. The X-band ESR spectra of Cu(II) complexes were recorded on a EMX 1444 EPR spectrometer at room temperature (300 K) in solid state using TCNE as g marker (g = 2.00277).…”

“…Studies on biological activity of Schiff bases derived from isatin and their metal complexes showed significant enhancement of antibacterial and antifungal activity of the isatin derivatives on complexation 3 . Over the recent years, more attention has been focused on the coordination chemistry and biological properties of different metal complexes of isatin-thio-semicabazones 4,5 , bis-(thio-semicarbazones 6 ), semicarbazones 7 and hydrazones 8,9 in order to establish a possible relationship between chemical structure and biological activity. Schiff and Mannich bases of isatin were reported to possess antibacterial 10 , antifungal 11 , antiviral 12 , anti-HIV 13 , anti protozoal 14 , antiviral 15 and anticancer 16 .…”

Quantum Chemical Calculations for some Isatin Thiosemicarbazones

“…Derivatives of isatin are reported to be present in mammalian tissues and body fluids (Casas et al, 1996;Agrawal & Sartorelli, 1978;Casas et al, 1994;Medvedev et al, 1998;Boon, 1997;Pandeya & Dimmock, 1993;Rodríguez-Argüelles et al, 1999;Casas et al, 2000) and possess antibacterial (Daisley & Shah, 1984), antifungal (Piscopo et al, 1987), and anti-HIV (Pandeya et al, 1998(Pandeya et al, , 1999 activities. N-methylisatin--4', 4' -diethylthiosemicarbazone were also reported to have activity against the viruses such as cytomegalo and moloney leukemia viruses (Sherman et al, 1980;Ronen et al, 1987).…”