Reactions of healing wounds and granulation tissue in man to auto-thiersch, autodermal, and homodermal grafts

Gillman, Theodore; Penn, Jack; Bronks, Doris; Roux, Marie

doi:10.1016/s0007-1226(53)80029-9

Cited by 78 publications

(10 citation statements)

References 31 publications

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“…The subse¬ quent surface whitening reflects a decrease in vascularity of the granulation zone just deep to the epidermis, and it has been documented previously in the healing of second-degree burns.43 The decrease in follicles found in both wounds is consistent with the reduction and re¬ modeling of skin after a second-degree burn or midder¬ mal excision, as has been reported in previous stud¬ ies. 44,47 The analogy to early burn healing in the lasercreated wounds may permit use of this pulsed laser-swine skin model to create uniform burns for healing studies. At 6 weeks, the end of the study, the histologie features and gross appearance of both healed wounds are similar.…”

Section: Days 14 Through 42mentioning

confidence: 99%

Middermal Wound Healing

et al. 1992

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Section: Days 14 Through 42mentioning

confidence: 99%

Middermal Wound Healing

et al. 1992

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“…(Dann, Glucksmann and Tansley, 1941 ;McMinn, 1960;Gillman, 1968;Peacock and Van Winkle, 1970). In addition, it is known, that at a later stage well formed down-growths or "pseudo rete pegs" extend from the lower surface of the newly formed epithelium into the connective tissue of the wound (Billingham and Reynolds, 1952;Gillman et al, 1953;Winter, 1964; Peacock and Van Winkle), but apart from these generalised facts little information is available in the literature on the changes in thickness that occur both at the wound edge and over the surface of the wound during the healing of excised full-thickness skin wounds. The following account describes such changes as they occur in the thoracic and metatarsal region of the dog and an attempt is made to explain the significance of the findings.…”

mentioning

confidence: 99%

Changes in epithelial thickness during the healing of excised full‐thickness skin wounds

Winstanley

1974

The Journal of Pathology

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“…While this is convenient in the present circumstances, it does not deny the influence that epithelium may have on connective tissue or vice versa. Such influences have been studied almost exclusively in skin, and their importance has been stressed by Gillman et al (1953) in connexion with the problems raised by skin grafting. They may also be significant in the pathogenesis of skin cancer (Gillman et al 1955c), but these subjects do not fall within the scope of this article.…”

Section: Discussionmentioning

confidence: 99%

The Cytology of Wound Healing of Body Surfaces in Mammals

Johnson¹,

McMinn²

1960

Biological Reviews

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SUMMARY The cytological aspects of the repair of wounds with loss of substance in the skin, cornea and a number of mucous, serous and synovial membranes in mammals (laboratory animals and man) have been reviewed. It is emphasized that, as in the last century, the majority of studies of wound healing continue to be carried out on skin, and the need for examining repair processes in other organs is stressed. While most of the evidence indicates that epithelium regenerates from old epithelium at the wound margin, the surfaces of serous and synovial membranes are probably repaired by metaplasia of underlying connective tissue cells, assisted by the implantation of islands of surface cells that have desquamated from adjacent surfaces. The epithelia of the gall‐bladder and urinary bladder (in the cat) display abundant evidence of mitosis in migrating cells. Mitosis in spreading cells has also been observed in ileal and rectal epithelium. While migration remains a primary factor in epithelial repair, the role of mitosis has possibly been underestimated in the past. The origin of the connective tissue cells of granulation tissue remains an enigma. There is evidence suggesting that the fibrocytes of the dermis do not proliferate, and that new connective tissue cells are haematogenous in origin. The endothelial (vascular and lymphatic) elements of granulation tissue originate by budding from pre‐existing vessels. There is doubt whether mitosis occurs in such endothelial cells. In the repair of mucous membranes in the alimentary tract, new gland formation is observed regularly in the stomach, duodenum and ileum in all the species that have been investigated, including man. The colon and rectum appear to exhibit less regenerative capacity than higher levels of the alimentary tract, for there is no consistent evidence for new gland formation in these viscera. No universally applicable explanation is yet forthcoming for the accumulation of glycogen that can be detected histochemically in many, but not all, of the regenerating epithelia that have so far been studied. Among the urgent items on which cytological research might be prosecuted in the future are: the possible role of metaplasia of connective tissue cells in the production of new epithelium, mitosis in migrating epithelium, the factors regulating the initiation and cessation of mitosis, the problem of the origin of new connective tissue cells, and the causes of contraction. Compared with the number of purely morphological studies, histochemistry and autoradiography have not often been wedded to the problems of repair, while the whole field of wound healing at the cellular level awaits study with the electron microscope.

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Reactions of healing wounds and granulation tissue in man to auto-thiersch, autodermal, and homodermal grafts

Cited by 78 publications

References 31 publications

Middermal Wound Healing

Middermal Wound Healing

Changes in epithelial thickness during the healing of excised full‐thickness skin wounds

The Cytology of Wound Healing of Body Surfaces in Mammals

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