Reactions of hydroxyl radical with bergenin, a natural poly phenol studied by pulse radiolysis

Singh, Umang; Barik, Atanu; Priyadarsini, K. Indira

doi:10.1016/j.bmc.2009.06.055

Cited by 17 publications

(13 citation statements)

References 41 publications

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“…The study clearly showed that the principal radical scavengers of B. cordifolia were not arbutin ( 1 ) and bergenin ( 2 ) but the trace compounds 3–5 . The finding of the major compound, bergenin ( 1 ) as a weak antioxidant agent is consistent with previous studies on this compound (Singh et al , ). On a molar basis, compounds 3–5 were more potent than the standard reference compounds, rutin and gallic acid.…”

Section: Resultssupporting

confidence: 92%

Phytochemical, Antioxidant and Anti‐α‐glucosidase Activity Evaluations of Bergenia cordifolia

Roselli

Lentini

Habtemariam

2011

Phytotherapy Research

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The antioxidant, anti-α-glucosidase and anticholinesterase activity of the leaves and rhizomatous extract of Bergenia cordifolia were investigated. The rhizomes extract that showed a higher degree of 1,1-diphenyl-2-picrylhydrazyl radical scavenging and anti-α-glucosidase activity than reference compounds (rutin and acarbose respectively) were subjected to phytochemical analysis. The study revealed that previously unknown minor constituents from the plant, (+)-catechin 3-O-gallate, (+)-catechin 3,5-di-O-gallate and 1,2,4,6-tetra-O-galloyl-β-D-glucopyranoside, were the radical scavenging and anti-α-glucosidase principles. These compounds as well as the crude extracts were weak acetylcholienesterase inhibitors, suggesting a higher degree of selectivity against α-glucosidase enzyme. In comparison with the minor constituents, the previously known major constituents of the plant, bergenin and arbutin, were poor radical scavengers and enzyme inhibitors.

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Section: Resultssupporting

confidence: 92%

Phytochemical, Antioxidant and Anti‐α‐glucosidase Activity Evaluations of Bergenia cordifolia

Roselli

Lentini

Habtemariam

2011

Phytotherapy Research

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“…Bergenin (1) itself is a good scavenger of hydroxyl radicals but not so effective in scavenging other free radicals like superoxide radical and DPPH [33,35,41,42,50,52,55,64,110,111,148,188,189]. Significant antioxidant activity of bergenin in hydrogen peroxide, ABTS, DPPH and inhibition of lipid peroxidation assays with IC 50 values 32.54, 75.06, 165.35 and 365.12 μg/mL, respectively, was reported by Srinivasan et al [54].…”

Section: Antioxidant Activitymentioning

confidence: 63%

“…Reactions of pulse radiolytically generated hydroxyl (•OH) radicals with bergenin have been studied, which showed that bergenin radical products are formed by •OH radical addition to the phenyl ring and H-atom abstraction from the C ring in bergenin [188]. In most of the cases, •OH radical reacts with natural polyphenols to produce phenoxyl radicals; in contrast, in the case of bergenin, reducing radical adducts are the major transients formed, which may react with oxygen forming peroxyl type radicals.…”

Section: Antioxidant Activitymentioning

confidence: 99%

Diversity, pharmacology and synthesis of bergenin and its derivatives: Potential materials for therapeutic usages

Bajracharya

2015

Fitoterapia

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“…The molecular formula and chemical structure are shown in Table 1. Bergenin exhibits antiparasitic, antihepatotoxic, antiviral, anti-HIV, antiarrhythmic, antiulcerogenic, neuroprotective, immunomodulatory, antioxidant, antimicrobial and anti-inflammatory properties [37]. Anti-HIV activity of bergenin was reported with an effective concentration (EC 50 ) of 40 μg/mL [38].…”

Section: Admet Studymentioning

confidence: 99%

Discovery of Fungal Metabolites Bergenin, Quercitrin and Dihydroartemisinin as Potential Inhibitors Against Main Protease of SARS-CoV-2

Patel

Vanzara²,

Patel³

et al. 2020

Preprint

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Emergence of severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) infection has given rise to COVID-19 pandemic, that is wreaking havoc worldwide. Therefore, there is an urgent need to find out novel drugs to combat SARS-CoV-2 infection. In this backdrop, the present study was aimed to assess potent bioactive compounds from different fungi as potential inhibitors of SARS-CoV-2 main protease (Mpro) using an in-silico analysis. Nearly 118 bioactive compounds were extracted from Dictyophora indusiata, Geassstrum triplex and Cyathus stercoreus and identified using HR LC/MS analysis. Of which, only bergenin (D. indusiata), quercitrin (G. triplex) and dihydroartemisinin (C. stercoreus) were selected based on their medicinal uses, binding score and active site covered. The 6LU7, a protein crystallographic structure of SARS-CoV-2 Mpro, was docked with bergenin, quercitrin and dihydroartemisinin using Autodock 4.2 and the binding energies obtained were -7.86, -10.29 and -7.20 kcal/mol, respectively. Bergenin, quercitrin and dihydroartemisinin formed hydrogen bond, electrostatic interactions and hydrophobic interactions with foremost active site amino acids THR190, GLU166, GLN189, GLY143, HIS163, HIS164, CYS145 and PHE140. Present investigation suggests that these three drugs may be used as alternative inhibitors against SARS-CoV-2 Mpro. However, further research is necessary to assess in vitro potential of these drugs. To the best of our knowledge, present investigation reported these three bioactive compounds of fungal origin for the first time.

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Reactions of hydroxyl radical with bergenin, a natural poly phenol studied by pulse radiolysis

Cited by 17 publications

References 41 publications

Phytochemical, Antioxidant and Anti‐α‐glucosidase Activity Evaluations of Bergenia cordifolia

Phytochemical, Antioxidant and Anti‐α‐glucosidase Activity Evaluations of Bergenia cordifolia

Diversity, pharmacology and synthesis of bergenin and its derivatives: Potential materials for therapeutic usages

Discovery of Fungal Metabolites Bergenin, Quercitrin and Dihydroartemisinin as Potential Inhibitors Against Main Protease of SARS-CoV-2

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