Reactions of monochloramine with bromine, tribromide, hypobromous acid and hypobromite: formation of bromochloramines

Gazda, Michael; Margerum, Dale W.

doi:10.1021/ic00079a022

Cited by 93 publications

(47 citation statements)

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“…The active component of t-butyl hydroperoxide was determined by iodometric titration with sodium thiosulfate. Sodium hypochlorite was standardized spectrophotometrically [36]. Sodium bromide, sodium perchlorate and phenolsulfonephthalein were obtained from Aldrich and were used as received.…”

Section: Methodsmentioning

confidence: 99%

Modeling the haloperoxidases: Reversible oxygen atom transfer between bromide ion and an oxo-Mn(V) porphyrin

Lahaye

Groves

2007

Journal of Inorganic Biochemistry

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Section: Methodsmentioning

confidence: 99%

Modeling the haloperoxidases: Reversible oxygen atom transfer between bromide ion and an oxo-Mn(V) porphyrin

Lahaye

Groves

2007

Journal of Inorganic Biochemistry

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“…(HOBr λ max at 260 nm, ε l 100 M −" :cm −" : OBr − λ max at 329 nm, ε 332 M −" :cm −" ; OCl − λ max at 292 nm, ε 350 M −" :cm −" [29].) Because of the instability of HOBr\OBr − , the solutions were generated within 30 min of use and adjusted to pH 7.4 immediately before addition to the red cells.…”

Section: Experimental Materialsmentioning

confidence: 99%

Comparison of human red cell lysis by hypochlorous and hypobromous acids: insights into the mechanism of lysis

Vissers

Carr

Chapman

1998

Biochemical Journal

104

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Human red blood cells are lysed by the neutrophil-derived oxidant hypochlorous acid (HOCl), although the mechanism of lysis is unknown. Hypobromous acid (HOBr), a similarly reactive oxidant, lysed red cells approx. 10-fold faster than HOCl. Therefore we compared the effects of these oxidants on thiols, membrane lipids and proteins to determine which reactions are associated with lysis. There was no difference in the loss of reduced glutathione or membrane thiols with either oxidant, but HOBr reacted more readily with membrane lipids and proteins. Bromohydrin derivatives of phospholipids and cholesterol were seen at approx. one-tenth the level of oxidant than chlorohydrins were. However, these products were detected only with high concentrations of HOCl or HOBr, which caused instant haemolysis. Membrane protein modification occurred at much lower doses of oxidant and was more closely correlated with lysis. SDS/PAGE analysis showed that band 3, the anion transport protein, was lost at the lowest dose of HOBr and at the higher concentrations of HOCl. Labelling the red cells with eosin 5-maleimide, a fluorescent label for band 3, suggested possible clustering of this protein in oxidant-exposed cells. There was also irreversible cross-linking of all the major membrane proteins; this reaction occurred more readily with HOBr. The results indicate that membrane protein modification is the reaction responsible for HOCl-mediated lysis. These effects, and particularly cross-link formation, might result in clustering of band 3 and other membrane and cytoskeletal proteins to form haemolytic pores.

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“…After 24 hours aging, the 50 mM CTABr etchant solution showed a color change from colorless to light yellow. An absorption peak at 265 nm and 390 nm can be then observed in the UV-Vis spectra (see figure S2), indicative of Br 3 -25 and Br 2 formation respectively 21 . Moreover, HBrO, which shall show very weak absorption around 260 nm 21 , can also generate from Br 2 solution 22 ( figure S2).…”

mentioning

confidence: 99%

“…An absorption peak at 265 nm and 390 nm can be then observed in the UV-Vis spectra (see figure S2), indicative of Br 3 -25 and Br 2 formation respectively 21 . Moreover, HBrO, which shall show very weak absorption around 260 nm 21 , can also generate from Br 2 solution 22 ( figure S2). However, due to the strong absorption of Br 3 -at 265 nm which is very close to that of HBrO at 260 nm, the HBrO absorption peak cannot be revealed in our 30 experiment.…”

mentioning

confidence: 99%

Reshaping anisotropic gold nanoparticles through oxidative etching: the role of the surfactant and nanoparticle surface curvature

et al. 2015

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We report an investigation on the effect of stabilization agents and surface curvatures on oxidative etching of three classes of anisotropically shaped gold nanoparticles namely, rods, bipyramids and prisms. In particular, the dual role of the 10 stabilizing agent CTAB in the etching process is explored, showing how it acts both as a source of bromine ions, accelerating etching and as a protection agent, resulting in anisotropic reshaping.

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Reactions of monochloramine with bromine, tribromide, hypobromous acid and hypobromite: formation of bromochloramines

Cited by 93 publications

References 0 publications

Modeling the haloperoxidases: Reversible oxygen atom transfer between bromide ion and an oxo-Mn(V) porphyrin

Modeling the haloperoxidases: Reversible oxygen atom transfer between bromide ion and an oxo-Mn(V) porphyrin

Comparison of human red cell lysis by hypochlorous and hypobromous acids: insights into the mechanism of lysis

Reshaping anisotropic gold nanoparticles through oxidative etching: the role of the surfactant and nanoparticle surface curvature

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