Reactions of periodontal ligament epithelial cell clusters and OX6-immunopositive cells to experimental tooth movement and periodontitis

Tadokoro, Osamu; Kawahara, Ichisuke; Vandevska‐Radunovic, Vaska

doi:10.1111/j.1600-0765.2011.01376.x

Cited by 3 publications

(2 citation statements)

References 34 publications

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“…[23242526] Experimental animal models are used to evaluate the etiopathogenesis, clinical characteristics, and histological and immunologic aspects of periodontal disease. [2728293031]…”

Section: Various Animal Models Usedmentioning

confidence: 99%

Ethical guidelines, animal profile, various animal models used in periodontal research with alternatives and future perspectives

Pasupuleti¹,

Shetty²,

Salwaji³

2016

J Indian Soc Periodontol

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Laboratory animal models serve as a facilitator to investigate the etiopathogenesis of periodontal disease, are used to know the efficacy of reconstructive and regenerative procedures, and are also helpful in evaluation of newer therapeutic techniques including laser and implant therapies prior to application in the human beings. The aim of this review is to know the different animal models used in various specialties of dental research and to know the ethical guidelines prior to the usage of experimental models with main emphasis on how to refine, replace, and reduce the number of animal models usage in the laboratory. An online search for experimental animal models used in dental research was performed using MEDLINE/PubMed database. Publications from 2009 to May 2013 in the specialty of periodontics were included in writing this review. A total of 652 references were published in PubMed/MEDLINE databases based on the search terms used. Out of 245 studies, 241 were related to the periodontal research published in English from 2009 to 2013. Relevant papers were chosen according to the inclusion and exclusion criteria. After extensive electronic and hand search on animal models, it has been observed that various animal models were used in dental research. Search on animal models used for dental research purpose revealed that various animals such as rats, mice, guinea pigs, rabbit, beagle dogs, goats, and nonhuman primates were extensively used. However, with the new advancement of ex vivo animal models, it has become easy to investigate disease pathogenesis and to test the efficacy of newer therapeutic modalities with the reduced usage of animal models. This review summarized the large amount of literature on animal models used in periodontal research with main emphasis on ethical guidelines and on reducing the animal model usage in future perspective.

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“…[23242526] Experimental animal models are used to evaluate the etiopathogenesis, clinical characteristics, and histological and immunologic aspects of periodontal disease. [2728293031]…”

Section: Various Animal Models Usedmentioning

confidence: 99%

Ethical guidelines, animal profile, various animal models used in periodontal research with alternatives and future perspectives

Pasupuleti¹,

Shetty²,

Salwaji³

2016

J Indian Soc Periodontol

View full text Add to dashboard Cite

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“…The concentration of P. gingivalis is directly related to the onset of the destruction of the epithelial barrier [6]. In response to the increased forces (such as orthodontic forces) on the teeth, the epithelial insertion becomes modified, setting off an immunological response in addition to inflammation [7].…”

Section: Introductionmentioning

confidence: 99%

Computer-assisted identification of the gingival sulcus and periodontal epithelial junction on high-frequency ultrasound images

et al. 2015

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The primary aim of this study was to demonstrate that periodontal ultrasonography is a reliable method with which to identify and evaluate the attachment level of the gingival junctional epithelium. A secondary aim was to devise an automated computer-assisted method that allows the examiner to more easily identify the gingival sulcus contour on ultrasound images. Material and methods: This in vitro study was carried out on 36 sites on the lingual surface of eight pig mandibles. For each site, periodontal ultrasonography was performed by the same examiner, using DermaScan C Cortex Technology (Denmark) with a 20-MHz transducer. Subsequently, the mandibles were sectioned with a microtome and examined by direct microscopy. To facilitate identification of the gingival sulcus on ultrasound images, a computational method was adopted. Results: Computer processing of the ultrasound images slightly modified the contour of the gingival sulcus. The absolute mean differences in the linear measurements of the Dermascan-automated computer-generated values and the corresponding values of microscopy, which is the gold standard, varied between 0.06 and 1.75 mm. Statistical analysis showed that with respect to the gingival sulcus height, the correlation between the computer-processed ultrasound images and the direct microscopy images was stronger than the correlation between the non-processed ultrasound images and those from direct microscopy. Conclusions: Ultrasonographic examination of the periodontal tissues allows the examiner to localize the gingival epithelial attachment level and provides substantial data regarding the soft gingival tissues.

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Effect of minocycline on induced glial activation by experimental tooth movement

Deguchi

Adachi

Kamioka

et al. 2016

American Journal of Orthodontics and Dentofacial Orthopedics

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Reactions of periodontal ligament epithelial cell clusters and OX6-immunopositive cells to experimental tooth movement and periodontitis

Cited by 3 publications

References 34 publications

Ethical guidelines, animal profile, various animal models used in periodontal research with alternatives and future perspectives

Ethical guidelines, animal profile, various animal models used in periodontal research with alternatives and future perspectives

Computer-assisted identification of the gingival sulcus and periodontal epithelial junction on high-frequency ultrasound images

Effect of minocycline on induced glial activation by experimental tooth movement

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